The oscillation of mitotic kinase governs cell cycle latches in mammalian cells

• Published in: Journal of cell science Vol. 137; no. 3
• Main Authors: Dragoi, Calin-Mihai, Kaur, Ekjot, Barr, Alexis R., Tyson, John J., Novák, Béla
• Format: Journal Article
• Language: English
• Published: England The Company of Biologists Ltd 01.02.2024
• Subjects: Anaphase-Promoting Complex-Cyclosome - metabolism; Animals; Cdc20 Proteins - metabolism; Cell Cycle; Cell Cycle Proteins - metabolism; Cyclin-Dependent Kinases - metabolism; Cyclins; Mammals - metabolism; Mitosis; Endocycles; Biochemical switches; Size control; Hysteresis; Bistability

The mammalian cell cycle alternates between two phases – S-G2-M with high levels of A- and B-type cyclins (CycA and CycB, respectively) bound to cyclin-dependent kinases (CDKs), and G1 with persistent degradation of CycA and CycB by an activated anaphase promoting complex/cyclosome (APC/C) bound to...