Pro‐inflammatory role of transient receptor potential canonical channel 6 in the pathogenesis of chronic rhinosinusitis with nasal polyps

• Published in: International forum of allergy & rhinology Vol. 8; no. 11; pp. 1334 - 1341
• Main Authors: Tang, Ru, Li, Zhi‐Peng, Li, Ming‐Xian, Li, Da‐Wei, Ye, Hai‐Bo, Su, Kai‐Ming, Lin, Hai, Zhang, Wei‐Tian
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.11.2018
• Subjects: calcium; Calcium (intracellular); Calcium channels; Cell culture; Enzyme-linked immunosorbent assay; eosinophil; Epithelial cells; Flow cytometry; Glycerol; Imidazole; Immunohistochemistry; Inflammation; Leukocytes (eosinophilic); Leukocytes (neutrophilic); Lipopolysaccharides; mRNA; Orai1; Orai1 protein; Pathogenesis; Polymerase chain reaction; Polyps; Rhinitis; Rhinosinusitis; Sinusitis; STIM1 protein; stromal interaction molecule 1; Transient receptor potential proteins; Western blotting; Orai1; calcium; eosinophil; inflammation; stromal interaction molecule 1

Background The pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP) has not been fully elucidated. This study sought to explore the role and mechanism of transient receptor potential canonical channel 6 (TRPC6) in the pathogenesis of CRSwNP. Methods Immunohistochemistry (IHC) was employ...