Yield of karyotyping in children with developmental delay and/or dysmorphic features in Sohag University Hospital, Upper Egypt

• Published in: The Egyptian journal of medical human genetics Vol. 19; no. 3; pp. 253 - 259
• Main Authors: Sadek, Abdelrahim A., Mohamed, Mostafa Ashry
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Elsevier B.V 01.07.2018; Egyptian Society of Human Genetics; Springer Nature B.V; SpringerOpen
• Subjects: Age; Birth order; Children; Chromosome aberrations; Chromosomes; Down syndrome; Down's syndrome; Dysmorphic features; EEG; Families & family life; Family medical history; Genetic screening; Global developmental delay (GDD); Hospitals; Hybridization; Hyperactivity; Intellectual disabilities; Karyotyping; Medical imaging; Microcephaly; Neuroimaging; Neurology; NMR; Nuclear magnetic resonance; Pediatrics; Statistical analysis; Structural chromosomal abnormalities; Trisomy; Egypt; Global developmental delay (GDD); Dysmorphic features; Down syndrome; Karyotyping; Structural chromosomal abnormalities

Global developmental delay (GDD) represents a measurable lag in a young child's achievement of developmental milestones compared to age matched children. Affection of two or more developmental domains is fundamental for assumption of GDD. Many chromosomal abnormalities are responsible for devel...