Effect of antibiotics in fibrin sealant on healing colonic anastomoses in the rat

• Published in: British journal of surgery Vol. 79; no. 6; p. 525
• Main Authors: van der Ham, A C, Kort, W J, Weijma, I M, van den Ingh, H F, Jeekel, H
• Format: Journal Article
• Language: English
• Published: England 01.06.1992
• Subjects: Anastomosis, Surgical; Animals; Anti-Bacterial Agents - pharmacology; Collagen - metabolism; Colon - metabolism; Colon - pathology; Colon - surgery; Colonic Diseases - etiology; Fibrin Tissue Adhesive - pharmacology; Male; Rats; Rats, Inbred Strains; Tissue Adhesions - etiology; Wound Healing - drug effects

In 90 rats a colonic anastomosis was constructed with 12 interrupted 7/0 polypropylene sutures. Group 1 (n = 30) served as a control group. In group 2 (n = 30) the anastomosis was sealed with fibrin adhesive and in group 3 (n = 30) a mixture of fibrin, clindamycin and cefotaxime was used. On days 2,...