Regulation of phagocytosis by Rho GTPases

• Published in: Small GTPases Vol. 6; no. 2; pp. 89 - 99
• Main Authors: Mao, Yingyu, Finnemann, Silvia C
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.01.2015
• Subjects: Animals; Cellular signalling networks and Rho GTPases: major crossroads: Review; clearance; digestion; engulfment; f-actin recruitment; Humans; internalization; Macrophage-1 Antigen - metabolism; membrane receptors; phagocytic cup; Phagocytosis; phagosome; Receptors, Fc - metabolism; rho GTP-Binding Proteins - metabolism; Second Messenger Systems; engulfment; f-actin recruitment; phagocytic cup; digestion; clearance; internalization; phagosome; membrane receptors

Phagocytosis is defined as a cellular uptake pathway for particles of greater than 0.5 μm in diameter. Particle clearance by phagocytosis is of critical importance for tissue health and homeostasis. The ultimate goal of anti-pathogen phagocytosis is to destroy engulfed bacteria or fungi and to stimu...