Bismuth improves efficacy of proton‐pump inhibitor clarithromycin, metronidazole triple Helicobacter pylori therapy despite a high prevalence of antimicrobial resistance

• Published in: Helicobacter (Cambridge, Mass.) Vol. 23; no. 3; pp. e12485 - n/a
• Main Authors: Long, Xiaohua, Chen, Qi, Yu, Lou, Liang, Xiao, Liu, Wenzhong, Lu, Hong
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.06.2018
• Subjects: Adult; Aged; Allergies; allergy; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - adverse effects; Antibiotics; Antiinfectives and antibacterials; Antimicrobial agents; Antimicrobial resistance; Bismuth; Bismuth - administration & dosage; Bismuth - adverse effects; Breath Tests; China; Clarithromycin; Clarithromycin - administration & dosage; Clarithromycin - adverse effects; Dilution; Drug Resistance, Bacterial; Drug Therapy, Combination; Eradication; Esomeprazole - administration & dosage; Esomeprazole - adverse effects; Female; Helicobacter Infections - diagnosis; Helicobacter Infections - drug therapy; Helicobacter pylori; Helicobacter pylori - isolation & purification; high dose of metronidazole; Humans; Inhibitors; Male; Metronidazole; Metronidazole - administration & dosage; Metronidazole - adverse effects; Microbial Sensitivity Tests; Middle Aged; Motivation; Omeprazole; Patients; Penicillin; Proton pump inhibitors; Proton Pump Inhibitors - administration & dosage; Proton Pump Inhibitors - adverse effects; Randomization; Therapy; Treatment Outcome; Urea; China; allergy; high dose of metronidazole; Helicobacter pylori; bismuth

Background Helicobacter pylori (H. pylori) eradication has become increasingly difficult especially for penicillin allergy patients. Aims To evaluate the efficacy of adding bismuth or high‐dose metronidazole to an H. pylori eradication regimen containing a proton‐pump inhibitor, clarithromycin, and...