TETRONOTHIODIN, A NOVEL CHOLECYSTOKININ TYPE-B RECEPTOR ANTAGONIST PRODUCED BY Streptomyces sp. NR0489 II. ISOLATION, CHARACTERIZATION AND BIOLOGICAL ACTIVITIES

• Published in: Journal of antibiotics Vol. 46; no. 1; pp. 11 - 17
• Main Authors: OHTSUKA, TATSUO, KOTAKI, HIROMICHI, NAKAYAMA, NOBORU, ITEZONO, YOSHIKO, SHIMMA, NOBUO, KUDOH, TSUTOMU, KUWAHARA, TOSHIKAZU, ARISAWA, MIKIO, YOKOSE, KAZUTERU, SETO, HARUO
• Format: Journal Article
• Language: English
• Published: Tokyo JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 01.01.1993; Japan Antibiotics Research Association
• Subjects: Animals; Biological and medical sciences; Calcium - metabolism; Cell Line; Cerebral Cortex - drug effects; Chromatography, Gel; Chromatography, High Pressure Liquid; Furans - chemistry; Furans - isolation & purification; Furans - pharmacology; Magnetic Resonance Spectroscopy; Medical sciences; Miscellaneous; Neuropharmacology; Neurotransmitters. Neurotransmission. Receptors; Pancreas - drug effects; Pharmacology. Drug treatments; Pituitary Gland, Anterior - drug effects; Rats; Receptors, Cholecystokinin - antagonists & inhibitors; Sincalide - antagonists & inhibitors; Streptococcus - chemistry; Streptomyces; Thiophenes - chemistry; Thiophenes - isolation & purification; Thiophenes - pharmacology; Actinomycetales; Cholecystokinine receptor B; Streptomycetaceae; Streptomyces; Bacteria; Isolation; Actinomycetes; Antagonist; In vitro; Biological activity

A novel cholecystokinin type-B receptor antagonist named tetronothiodin has been isolated by column chromatography and preparative HPLC from the fermentation broth of Streptomyces sp. NR0489. Tetronothiodin inhibited the binding of CCK8 (C-terminal octapeptide of cholecystokinin) to rat cerebral cor...