Uncoupling of transcription and translation of Fanconi anemia (FANC) complex proteins during spermatogenesis

• Published in: Spermatogenesis Vol. 5; no. 1; p. e979061
• Main Authors: Jamsai, Duangporn, O'Connor, Anne E, O'Donnell, Liza, Lo, Jennifer Chi Yi, O'Bryan, Moira K
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 2015
• Subjects: DNA repair; Fanconi anemia; spermatid; spermatocyte; spermatogonia; translational regulation; spermatocyte; spermatogonia; translational regulation; Fanconi anemia; spermatid; DNA repair

Male germ cell genome integrity is critical for spermatogenesis, fertility and normal development of the offspring. Several DNA repair pathways exist in male germ cells. One such important pathway is the Fanconi anemia (FANC) pathway. Unlike in somatic cells, expression profiles and the role of the...