Genome-Wide SNP Analysis Reveals Distinct Origins of Trypanosoma evansi and Trypanosoma equiperdum

Trypanosomes cause a variety of diseases in man and domestic animals in Africa, Latin America, and Asia. In the Trypanozoon subgenus, Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense cause human African trypanosomiasis, whereas Trypanosoma brucei brucei, Trypanosoma evansi, and Trypan...

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Published inGenome biology and evolution Vol. 9; no. 8; pp. 1990 - 1997
Main Authors Cuypers, Bart, Van den Broeck, Frederik, Van Reet, Nick, Meehan, Conor J, Cauchard, Julien, Wilkes, Jonathan M, Claes, Filip, Goddeeris, Bruno, Birhanu, Hadush, Dujardin, Jean-Claude, Laukens, Kris, Büscher, Philippe, Deborggraeve, Stijn
Format Journal Article
LanguageEnglish
Published England Oxford University Press 01.08.2017
Subjects
Africa, Eastern
Africa, Western
Genes, Protozoan
Genome, Protozoan
Genome-Wide Association Study
Phylogeny
Polymorphism, Single Nucleotide
Trypanosoma - genetics
Trypanosoma evansi
Trypanozoon
whole genome sequencing
Trypansoma equiperdum
phylogeny
SNP analysis
Online AccessGet full text

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Abstract Trypanosomes cause a variety of diseases in man and domestic animals in Africa, Latin America, and Asia. In the Trypanozoon subgenus, Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense cause human African trypanosomiasis, whereas Trypanosoma brucei brucei, Trypanosoma evansi, and Trypanosoma equiperdum are responsible for nagana, surra, and dourine in domestic animals, respectively. The genetic relationships between T. evansi and T. equiperdum and other Trypanozoon species remain unclear because the majority of phylogenetic analyses has been based on only a few genes. In this study, we have conducted a phylogenetic analysis based on genome-wide SNP analysis comprising 56 genomes from the Trypanozoon subgenus. Our data reveal that T. equiperdum has emerged at least once in Eastern Africa and T. evansi at two independent occasions in Western Africa. The genomes within the T. equiperdum and T. evansi monophyletic clusters show extremely little variation, probably due to the clonal spread linked to the independence from tsetse flies for their transmission.
AbstractList Trypanosomes cause a variety of diseases in man and domestic animals in Africa, Latin America, and Asia. In the Trypanozoon subgenus, Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense cause human African trypanosomiasis, whereas Trypanosoma brucei brucei, Trypanosoma evansi, and Trypanosoma equiperdum are responsible for nagana, surra, and dourine in domestic animals, respectively. The genetic relationships between T. evansi and T. equiperdum and other Trypanozoon species remain unclear because the majority of phylogenetic analyses has been based on only a few genes. In this study, we have conducted a phylogenetic analysis based on genome-wide SNP analysis comprising 56 genomes from the Trypanozoon subgenus. Our data reveal that T. equiperdum has emerged at least once in Eastern Africa and T. evansi at two independent occasions in Western Africa. The genomes within the T. equiperdum and T. evansi monophyletic clusters show extremely little variation, probably due to the clonal spread linked to the independence from tsetse flies for their transmission.
Trypanosomes cause a variety of diseases in man and domestic animals in Africa, Latin America, and Asia. In the Trypanozoon subgenus, Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense cause human African trypanosomiasis, whereas Trypanosoma brucei brucei , Trypanosoma evansi , and Trypanosoma equiperdum are responsible for nagana, surra, and dourine in domestic animals, respectively. The genetic relationships between T. evansi and T. equiperdum and other Trypanozoon species remain unclear because the majority of phylogenetic analyses has been based on only a few genes. In this study, we have conducted a phylogenetic analysis based on genome-wide SNP analysis comprising 56 genomes from the Trypanozoon subgenus. Our data reveal that T. equiperdum has emerged at least once in Eastern Africa and T. evansi at two independent occasions in Western Africa. The genomes within the T. equiperdum and T. evansi monophyletic clusters show extremely little variation, probably due to the clonal spread linked to the independence from tsetse flies for their transmission.
Author Wilkes, Jonathan M
Deborggraeve, Stijn
Van Reet, Nick
Van den Broeck, Frederik
Cuypers, Bart
Dujardin, Jean-Claude
Laukens, Kris
Goddeeris, Bruno
Büscher, Philippe
Birhanu, Hadush
Meehan, Conor J
Claes, Filip
Cauchard, Julien
AuthorAffiliation 7 College of Veterinary Medicine, Mekelle University, Tigray, Ethiopia
4 Wellcome Trust Centre of Molecular Parasitology, University of Glasgow, United Kingdom
8 Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium
2 Department of Mathematics and Computer Sciences, University of Antwerp, Belgium
5 Food and Agriculture Organization of the United Nations (FAO), Regional Office for Asia and the Pacific, Bangkok, Thailand
1 Biomedical Sciences Department, Institute of Tropical Medicine, Antwerp, Belgium
3 Anses Dozulé Laboratory for Equine Diseases, Goustranville, France
6 Faculty of Bioscience Engineering, KU Leuven, Belgium
AuthorAffiliation_xml – name: 1 Biomedical Sciences Department, Institute of Tropical Medicine, Antwerp, Belgium
– name: 2 Department of Mathematics and Computer Sciences, University of Antwerp, Belgium
– name: 4 Wellcome Trust Centre of Molecular Parasitology, University of Glasgow, United Kingdom
– name: 3 Anses Dozulé Laboratory for Equine Diseases, Goustranville, France
– name: 6 Faculty of Bioscience Engineering, KU Leuven, Belgium
– name: 5 Food and Agriculture Organization of the United Nations (FAO), Regional Office for Asia and the Pacific, Bangkok, Thailand
– name: 8 Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium
– name: 7 College of Veterinary Medicine, Mekelle University, Tigray, Ethiopia
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Cites_doi 10.1126/science.1156296
10.1016/j.cell.2009.08.005
10.1016/0166-6851(87)90184-8
10.1016/j.pt.2005.05.010
10.1093/bioinformatics/btu033
10.1038/nature12516
10.1016/j.vetpar.2009.01.034
10.1038/msb.2011.75
10.1016/0014-4894(77)90055-8
10.1038/nmeth.1923
10.1016/0166-6851(90)90060-Y
10.1016/0169-4758(86)90011-6
10.1073/pnas.0711799105
10.1016/0014-4894(70)90120-7
10.1038/sj.emboj.7600862
10.1016/j.vetpar.2010.03.041
10.1016/S0304-4017(98)00146-0
10.1016/0169-4758(95)80129-4
10.1016/S1567-1348(02)00028-X
10.1016/S0166-6851(99)00218-2
10.1016/S0020-7519(02)00020-6
10.1073/pnas.1305404110
10.1056/NEJMoa063265
10.1371/journal.pntd.0004556
10.1371/journal.pntd.0000961
10.1371/journal.pntd.0000658
10.1186/s13071-015-1177-7
10.1126/science.1112642
10.1016/0014-4894(76)90110-7
10.1371/journal.pgen.1002453
10.1186/1475-9292-3-3
10.7150/jgen.17904
10.1016/j.molbiopara.2006.03.017
10.1093/gbe/evu222
10.1371/journal.pone.0147660
10.1093/bioinformatics/btp352
10.1093/molbev/msj030
10.1016/S0092-8674(00)81706-7
10.1016/j.ajhg.2013.09.002
10.1186/s13071-015-1129-2
10.1371/journal.pntd.0003404
10.1146/annurev.biochem.66.1.863
10.1016/j.resmic.2015.05.005
10.1016/j.pt.2008.06.007
10.1016/0166-6851(92)90215-6
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Issue 8
Keywords Trypanosoma evansi
Trypanozoon
whole genome sequencing
Trypansoma equiperdum
phylogeny
SNP analysis
Language English
License The Author 2017. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.
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References 18245376 - Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):1999-2004
16682088 - Mol Biochem Parasitol. 2006 Sep;149(1):1-9
10699254 - Mol Biochem Parasitol. 2000 Mar 5;106(2):249-60
15377385 - Kinetoplastid Biol Dis. 2004 Sep 17;3(1):3
16270030 - EMBO J. 2005 Dec 7;24(23):4029-40
1311051 - Mol Biochem Parasitol. 1992 Feb;50(2):189-96
23959897 - Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14741-6
27035661 - PLoS Negl Trop Dis. 2016 Apr 01;10 (4):e0004556
67961 - Exp Parasitol. 1977 Jun;42(1):6-13
26910229 - PLoS One. 2016 Feb 24;11(2):e0147660
26809473 - Elife. 2016 Jan 26;5:e11473
21988835 - Mol Syst Biol. 2011 Oct 11;7:539
23965626 - Nature. 2013 Sep 19;501(7467):430-4
15462856 - Parasitol Today. 1986 Sep;2(9):255-7
26515286 - Parasit Vectors. 2015 Oct 29;8:566
24024184 - Biomed Res Int. 2013;2013:194176
22388286 - Nat Methods. 2012 Mar 04;9(4):357-9
1969612 - Mol Biochem Parasitol. 1990 Mar;39(2):213-25
19505943 - Bioinformatics. 2009 Aug 15;25(16):2078-9
18715829 - Trends Parasitol. 2008 Oct;24(10):428-31
9865701 - Cell. 1998 Dec 11;95(6):839-46
20417035 - Vet Parasitol. 2010 Aug 4;171(3-4):200-6
17192540 - N Engl J Med. 2006 Dec 28;355(26):2752-6
28138343 - J Genomics. 2017 Jan 12;5:1-3
22291602 - PLoS Genet. 2012 Jan;8(1):e1002453
18451305 - Science. 2008 May 2;320(5876):677-81
4993889 - Exp Parasitol. 1970 Dec;28(3):521-34
12798017 - Infect Genet Evol. 2002 May;1(3):207-14
16020726 - Science. 2005 Jul 15;309(5733):416-22
20404998 - PLoS Negl Trop Dis. 2010 Apr 13;4(4):e658
19703392 - Cell. 2009 Aug 21;138(4):628-44
27073096 - MBio. 2016 Apr 12;7(2):e02198-15
9242927 - Annu Rev Biochem. 1997;66:863-917
9806490 - Vet Parasitol. 1998 Oct;79(2):95-107
24151595 - Biomed Res Int. 2013;2013:321237
976425 - Exp Parasitol. 1976 Dec;40(3):427-31
15923142 - Trends Parasitol. 2005 Jul;21(7):316-21
12117490 - Int J Parasitol. 2002 Aug;32(9):1071-84
3033499 - Mol Biochem Parasitol. 1987 Feb;23(1):31-8
9579216 - Ann Trop Med Parasitol. 1997 Dec;91(8):951-6
6287687 - Tropenmed Parasitol. 1982 Jun;33(2):113-8
3223785 - Ann Soc Belg Med Trop. 1988 Sep;68(3):233-40
23963174 - MBio. 2013 Aug 20;4(4):null
21347445 - PLoS Negl Trop Dis. 2011 Feb 08;5(2):e961
15275353 - Parasitol Today. 1995 Apr;11(4):131-3
26027775 - Res Microbiol. 2015 Jul-Aug;166(6):459-66
26467019 - Parasit Vectors. 2015 Oct 15;8:536
25287146 - Genome Biol Evol. 2014 Oct 05;6(10):2811-9
24451623 - Bioinformatics. 2014 May 1;30(9):1312-3
24094745 - Am J Hum Genet. 2013 Oct 3;93(4):687-96
19286320 - Vet Parasitol. 2009 May 12;161(3-4):194-200
16221896 - Mol Biol Evol. 2006 Feb;23(2):254-67
25568942 - PLoS Negl Trop Dis. 2015 Jan 08;9(1):e3404
( key 20170822062930_evx102-B60) 2004; 3
( key 20170822062930_evx102-B12) 2013; 110
( key 20170822062930_evx102-B40) 2008; 320
( key 20170822062930_evx102-B59) 2000; 106
( key 20170822062930_evx102-B38) 2013; 501
( key 20170822062930_evx102-B32) 2002; 32
( key 20170822062930_evx102-B41) 2015; 5
( key 20170822062930_evx102-B62) 2008; 24
( key 20170822062930_evx102-B28) 2012; 8
( key 20170822062930_evx102-B47) 2015; 8
( key 20170822062930_evx102-B3) 2005; 309
( key 20170822062930_evx102-B6) 2006; 149
( key 20170822062930_evx102-B18) 1986; 2
( key 20170822062930_evx102-B42) 1998; 95
( key 20170822062930_evx102-B20) 2017; 5
( key 20170822062930_evx102-B24) 2010; 4
( key 20170822062930_evx102-B34) 2016; 11
( key 20170822062930_evx102-B39) 2006; 355
( key 20170822062930_evx102-B30) 1992; 50
( key 20170822062930_evx102-B50) 2010; 171
( key 20170822062930_evx102-B4) 2016; 10
( key 20170822062930_evx102-B21) 1976; 40
( key 20170822062930_evx102-B9) 2009; 138
( key 20170822062930_evx102-B61) 1990; 39
( key 20170822062930_evx102-B26) 2012; 9
( key 20170822062930_evx102-B8) 2015; 9
( key 20170822062930_evx102-B13) 2013; 93
( key 20170822062930_evx102-B7) 1998; 79
( key 20170822062930_evx102-B10) 2005; 21
( key 20170822062930_evx102-B14) 2013; 2013
( key 20170822062930_evx102-B15) 2013; 2013
( key 20170822062930_evx102-B46) 2009; 161
( key 20170822062930_evx102-B2) 2011; 5
( key 20170822062930_evx102-B35) 2014; 6
( key 20170822062930_evx102-B64) 1997; 66
( key 20170822062930_evx102-B45) 1982; 33
( key 20170822062930_evx102-B33) 2011; 7
( key 20170822062930_evx102-B17) 2002; 1
( key 20170822062930_evx102-B19) 2013; 4
( key 20170822062930_evx102-B11) 2016; 7
( key 20170822062930_evx102-B36) 2014; 30
( key 20170822062930_evx102-B29) 2009; 25
( key 20170822062930_evx102-B23) 2006; 23
( key 20170822062930_evx102-B22) 1972
( key 20170822062930_evx102-B25) 2008; 105
( key 20170822062930_evx102-B1) 1988; 68
( key 20170822062930_evx102-B49) 1977; 42
( key 20170822062930_evx102-B37) 1997; 91
( key 20170822062930_evx102-B16) 2015; 166
( key 20170822062930_evx102-B5) 1987; 23
( key 20170822062930_evx102-B31) 2005; 24
( key 20170822062930_evx102-B27) 1970; 28
( key 20170822062930_evx102-B63) 1995; 11
( key 20170822062930_evx102-B48) 2015; 8
References_xml – volume: 91
  start-page: 951
  year: 1997
  ident: key 20170822062930_evx102-B37
  article-title: Confirmation of two distinct classes of zymodemes of Trypanosoma brucei infecting man and wild mammals in Côte d'Ivoire: suspected difference in pathogenicity
  publication-title: Ann Trop Med Parasitol
– volume: 320
  start-page: 677
  year: 2008
  ident: key 20170822062930_evx102-B40
  article-title: A haptoglobin–hemoglobin receptor conveys innate immunity to Trypanosoma brucei in humans
  publication-title: Science
  doi: 10.1126/science.1156296
– volume: 138
  start-page: 628
  year: 2009
  ident: key 20170822062930_evx102-B9
  article-title: Importing mitochondrial proteins: machineries and mechanisms
  publication-title: Cell
  doi: 10.1016/j.cell.2009.08.005
– volume: 23
  start-page: 31
  year: 1987
  ident: key 20170822062930_evx102-B5
  article-title: Kinetoplast DNA of Trypanosoma evansi
  publication-title: Mol Biochem Parasitol
  doi: 10.1016/0166-6851(87)90184-8
– volume: 21
  start-page: 316
  year: 2005
  ident: key 20170822062930_evx102-B10
  article-title: Trypanosoma equiperdum: master of disguise or historical mistake?
  publication-title: Trends Parasitol
  doi: 10.1016/j.pt.2005.05.010
– volume: 30
  start-page: 1312
  year: 2014
  ident: key 20170822062930_evx102-B36
  article-title: RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btu033
– volume: 501
  start-page: 430
  year: 2013
  ident: key 20170822062930_evx102-B38
  article-title: Mechanism of Trypanosoma brucei gambiense resistance to human serum
  publication-title: Nature
  doi: 10.1038/nature12516
– volume: 33
  start-page: 113
  year: 1982
  ident: key 20170822062930_evx102-B45
  article-title: Epidemiological studies on the animal reservoir of Gambiense sleeping sickness. Part III. Characterization of Trypanozoon stocks by isoenzymes and sensitivity to human serum
  publication-title: Tropenmedizin und Parasitologie
– volume: 161
  start-page: 194
  year: 2009
  ident: key 20170822062930_evx102-B46
  article-title: Molecular profiles of Venezuelan isolates of Trypanosoma sp. by random amplified polymorphic DNA method
  publication-title: Veterinary Parasitol.
  doi: 10.1016/j.vetpar.2009.01.034
– volume: 7
  start-page: 539.
  year: 2011
  ident: key 20170822062930_evx102-B33
  article-title: Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega
  publication-title: Mol Syst Biol
  doi: 10.1038/msb.2011.75
– volume: 2013
  start-page: 194176
  year: 2013
  ident: key 20170822062930_evx102-B15
  article-title: Trypanosoma evansi and surra: a review and perspectives on origin, history, distribution, taxonomy, morphology, hosts, and pathogenic effects
  publication-title: Biomed Res Int
– volume: 42
  start-page: 6
  year: 1977
  ident: key 20170822062930_evx102-B49
  article-title: Trypanosoma equiperdum: étude des variations antigéniques au cours de la trypanosomose experimentale du lapin
  publication-title: Exp Parasitol.
  doi: 10.1016/0014-4894(77)90055-8
– volume: 9
  start-page: 357
  year: 2012
  ident: key 20170822062930_evx102-B26
  article-title: Fast gapped-read alignment with Bowtie 2
  publication-title: Nat Methods
  doi: 10.1038/nmeth.1923
– volume: 39
  start-page: 213
  year: 1990
  ident: key 20170822062930_evx102-B61
  article-title: The identification of Trypanosoma brucei subspecies using repetitive DNA sequences
  publication-title: Molecular and Biochemical Parasitology
  doi: 10.1016/0166-6851(90)90060-Y
– volume: 2
  start-page: 255
  year: 1986
  ident: key 20170822062930_evx102-B18
  article-title: Will the real Trypanosoma b. gambiense please stand up?
  publication-title: Parasitol Today
  doi: 10.1016/0169-4758(86)90011-6
– volume: 105
  start-page: 1999
  year: 2008
  ident: key 20170822062930_evx102-B25
  article-title: Adaptations of Trypanosoma brucei to gradual loss of kinetoplast DNA: Trypanosoma equiperdum and Trypanosoma evansi are petite mutants of T. brucei
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0711799105
– volume: 28
  start-page: 521
  year: 1970
  ident: key 20170822062930_evx102-B27
  article-title: Isolation of salivarian trypanosomes from man and other mammals using DEAE-cellulose
  publication-title: Exp Parasitol
  doi: 10.1016/0014-4894(70)90120-7
– volume: 24
  start-page: 4029
  year: 2005
  ident: key 20170822062930_evx102-B31
  article-title: The F1-ATP synthase complex in bloodstream stage trypanosomes has an unusual and essential function
  publication-title: EMBO J
  doi: 10.1038/sj.emboj.7600862
– volume: 171
  start-page: 200
  year: 2010
  ident: key 20170822062930_evx102-B50
  article-title: Efficacy of cymelarsan and diminasan against Trypanosoma equiperduminfections in mice and horses
  publication-title: Vet Parasitol.
  doi: 10.1016/j.vetpar.2010.03.041
– volume: 79
  start-page: 95
  year: 1998
  ident: key 20170822062930_evx102-B7
  article-title: Trypanosoma evansi and T. equiperdum: distribution, biology, treatment and phylogenetic relationship
  publication-title: Vet Parasitol
  doi: 10.1016/S0304-4017(98)00146-0
– volume: 11
  start-page: 131
  year: 1995
  ident: key 20170822062930_evx102-B63
  article-title: Is the broad range of hosts and geographical distribution of Trypanosoma evansi attributable to the loss of maxicircle kinetoplast DNA?
  publication-title: Parasitol Today
  doi: 10.1016/0169-4758(95)80129-4
– volume: 1
  start-page: 207
  year: 2002
  ident: key 20170822062930_evx102-B17
  article-title: The human serum resistance associated gene is ubiquitous and conserved in Trypanosoma brucei rhodesiense throughout East Africa
  publication-title: Infect Genet Evol
  doi: 10.1016/S1567-1348(02)00028-X
– volume: 5
  start-page: e11473.
  year: 2015
  ident: key 20170822062930_evx102-B41
  article-title: Population genomics reveals the origin and asexual evolution of human infective trypanosomes
  publication-title: Elife
– volume: 106
  start-page: 249
  year: 2000
  ident: key 20170822062930_evx102-B59
  article-title: Import of a constitutively expressed protein into mitochondria from procyclic and bloodstream forms of Trypanosoma brucei
  publication-title: Mol Biochem Parasitol
  doi: 10.1016/S0166-6851(99)00218-2
– volume: 32
  start-page: 1071
  year: 2002
  ident: key 20170822062930_evx102-B32
  article-title: Natural and induced dyskinetoplastic trypanosomatids: how to live without mitochondrial DNA
  publication-title: Int J Parasitol
  doi: 10.1016/S0020-7519(02)00020-6
– volume: 2013
  start-page: 321237
  year: 2013
  ident: key 20170822062930_evx102-B14
  article-title: Trypanosoma evansi and surra: a review and perspectives on transmission, epidemiology and control, impact, and zoonotic aspects
  publication-title: Biomed Res Int
– volume: 110
  start-page: 14741
  year: 2013
  ident: key 20170822062930_evx102-B12
  article-title: Single point mutations in ATP synthase compensate for mitochondrial genome loss in trypanosomes
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1305404110
– volume: 355
  start-page: 2752
  year: 2006
  ident: key 20170822062930_evx102-B39
  article-title: Human Trypanosoma evansi infection linked to a lack of apolipoprotein L-1
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa063265
– volume: 10
  start-page: e0004556.
  year: 2016
  ident: key 20170822062930_evx102-B4
  article-title: New Trypanosoma evansi type B isolates from Ethiopian dromedary camels
  publication-title: PLoS Negl Trop Dis
  doi: 10.1371/journal.pntd.0004556
– volume: 7
  start-page: e02198
  year: 2016
  ident: key 20170822062930_evx102-B11
  article-title: Apolipoprotein L1 variant associated with increased susceptibility to trypanosome infection
  publication-title: MBio
– volume: 5
  start-page: e961.
  year: 2011
  ident: key 20170822062930_evx102-B2
  article-title: Phylogeography and taxonomy of Trypanosoma brucei
  publication-title: PLoS Negl Trop Dis
  doi: 10.1371/journal.pntd.0000961
– volume: 4
  start-page: e658
  year: 2010
  ident: key 20170822062930_evx102-B24
  article-title: The genome sequence of Trypanosoma brucei gambiense, causative agent of chronic human African trypanosomiasis
  publication-title: PLoS Negl Trop Dis
  doi: 10.1371/journal.pntd.0000658
– volume: 8
  start-page: 566
  year: 2015
  ident: key 20170822062930_evx102-B47
  article-title: Erratum to: Molecular characterization and classification of Trypanosoma spp. Venezuelan isolates based on microsatellite markers and kinetoplast maxicircle genes
  publication-title: Parasit Vectors
  doi: 10.1186/s13071-015-1177-7
– volume: 309
  start-page: 416
  year: 2005
  ident: key 20170822062930_evx102-B3
  article-title: The genome of the African trypanosome Trypanosoma brucei
  publication-title: Science
  doi: 10.1126/science.1112642
– volume: 40
  start-page: 427
  year: 1976
  ident: key 20170822062930_evx102-B21
  article-title: Trypanosoma brucei: a rapid “matching” method for estimating the host's parasitemia
  publication-title: Exp Parasitol
  doi: 10.1016/0014-4894(76)90110-7
– volume: 8
  start-page: e1002453.
  year: 2012
  ident: key 20170822062930_evx102-B28
  article-title: Inference of population structure using dense haplotype data
  publication-title: PLoS Genet
  doi: 10.1371/journal.pgen.1002453
– volume: 3
  start-page: 3
  year: 2004
  ident: key 20170822062930_evx102-B60
  article-title: Variable Surface Glycoprotein RoTat 1.2 PCR as a specific diagnostic tool for the detection of Trypanosoma evansi infections
  publication-title: Kinetoplastid Biology and Disease
  doi: 10.1186/1475-9292-3-3
– volume: 5
  start-page: 1
  year: 2017
  ident: key 20170822062930_evx102-B20
  article-title: First draft genome sequence of the dourine causative agent: Trypanosoma equiperdum strain OVI
  publication-title: J Genomics
  doi: 10.7150/jgen.17904
– volume: 149
  start-page: 1
  year: 2006
  ident: key 20170822062930_evx102-B6
  article-title: Energy metabolism of trypanosomatids: adaptation to available carbon sources
  publication-title: Mol Biochem Parasitol
  doi: 10.1016/j.molbiopara.2006.03.017
– volume: 4
  start-page: 1
  year: 2013
  ident: key 20170822062930_evx102-B19
  article-title: Whole-genome sequencing of Trypanosoma brucei reveals introgression between subspecies that is associated with virulence
  publication-title: MBio
– volume: 6
  start-page: 2811
  year: 2014
  ident: key 20170822062930_evx102-B35
  article-title: Comparative genomics reveals multiple genetic backgrounds of human pathogenicity in the Trypanosoma brucei complex
  publication-title: Genome Biol Evol
  doi: 10.1093/gbe/evu222
– volume: 11
  start-page: e0147660
  year: 2016
  ident: key 20170822062930_evx102-B34
  article-title: De novo genome assembly shows genome wide similarity between Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0147660
– volume: 25
  start-page: 2078
  year: 2009
  ident: key 20170822062930_evx102-B29
  article-title: The sequence alignment/map format and SAMtools
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btp352
– volume: 23
  start-page: 254
  year: 2006
  ident: key 20170822062930_evx102-B23
  article-title: Application of phylogenetic networks in evolutionary studies
  publication-title: Mol Biol Evol
  doi: 10.1093/molbev/msj030
– volume: 95
  start-page: 839
  year: 1998
  ident: key 20170822062930_evx102-B42
  article-title: A VSG expression site-associated gene confers resistance to human serum in Trypanosoma rhodesiense
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)81706-7
– volume: 93
  start-page: 687
  year: 2013
  ident: key 20170822062930_evx102-B13
  article-title: Haplotype estimation using sequencing reads
  publication-title: Am J Hum Genet
  doi: 10.1016/j.ajhg.2013.09.002
– volume-title: The trypanosomes of mammals
  year: 1972
  ident: key 20170822062930_evx102-B22
– volume: 8
  start-page: 536
  year: 2015
  ident: key 20170822062930_evx102-B48
  article-title: Molecular characterization and classification of Trypanosoma spp. Venezuelan isolates based on microsatellite markers and kinetoplast maxicircle genes
  publication-title: Parasites and Vectors
  doi: 10.1186/s13071-015-1129-2
– volume: 9
  start-page: e3404
  year: 2015
  ident: key 20170822062930_evx102-B8
  article-title: Genome and phylogenetic analyses of Trypanosoma evansi reveal extensive similarity to T. brucei and multiple independent origins for dyskinetoplasty
  publication-title: PLoS Negl Trop Dis
  doi: 10.1371/journal.pntd.0003404
– volume: 66
  start-page: 863
  year: 1997
  ident: key 20170822062930_evx102-B64
  article-title: Protein import into mitochondria
  publication-title: Annu Rev Biochem
  doi: 10.1146/annurev.biochem.66.1.863
– volume: 166
  start-page: 459
  year: 2015
  ident: key 20170822062930_evx102-B16
  article-title: Liaisons dangereuses: sexual recombination among pathogenic trypanosomes
  publication-title: Res Microbiol
  doi: 10.1016/j.resmic.2015.05.005
– volume: 24
  start-page: 428
  year: 2008
  ident: key 20170822062930_evx102-B62
  article-title: What happens when Trypanosoma brucei leaves Africa
  publication-title: Trends Parasitol
  doi: 10.1016/j.pt.2008.06.007
– volume: 50
  start-page: 189
  year: 1992
  ident: key 20170822062930_evx102-B30
  article-title: Kinetoplast DNA and molecular karyotypes of Trypanosoma evansi and Trypanosoma equiperdum from China
  publication-title: Mol Biochem Parasitol
  doi: 10.1016/0166-6851(92)90215-6
– volume: 68
  start-page: 233
  year: 1988
  ident: key 20170822062930_evx102-B1
  article-title: A card agglutination test (CATT) for veterinary use based on an early VAT RoTat 1/2 of Trypanosoma evansi
  publication-title: Ann Soc Belg Med Trop
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Snippet Trypanosomes cause a variety of diseases in man and domestic animals in Africa, Latin America, and Asia. In the Trypanozoon subgenus, Trypanosoma brucei...
Trypanosomes cause a variety of diseases in man and domestic animals in Africa, Latin America, and Asia. In the Trypanozoon subgenus, Trypanosoma brucei...
SourceID pubmedcentral
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crossref
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SourceType Open Access Repository
Aggregation Database
Index Database
StartPage 1990
SubjectTerms Africa, Eastern
Africa, Western
Genes, Protozoan
Genome, Protozoan
Genome-Wide Association Study
Phylogeny
Polymorphism, Single Nucleotide
Trypanosoma - genetics
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Title Genome-Wide SNP Analysis Reveals Distinct Origins of Trypanosoma evansi and Trypanosoma equiperdum
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