Genome-Wide SNP Analysis Reveals Distinct Origins of Trypanosoma evansi and Trypanosoma equiperdum
Trypanosomes cause a variety of diseases in man and domestic animals in Africa, Latin America, and Asia. In the Trypanozoon subgenus, Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense cause human African trypanosomiasis, whereas Trypanosoma brucei brucei, Trypanosoma evansi, and Trypan...
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Published in | Genome biology and evolution Vol. 9; no. 8; pp. 1990 - 1997 |
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Main Authors | , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
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England
Oxford University Press
01.08.2017
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Abstract | Trypanosomes cause a variety of diseases in man and domestic animals in Africa, Latin America, and Asia. In the Trypanozoon subgenus, Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense cause human African trypanosomiasis, whereas Trypanosoma brucei brucei, Trypanosoma evansi, and Trypanosoma equiperdum are responsible for nagana, surra, and dourine in domestic animals, respectively. The genetic relationships between T. evansi and T. equiperdum and other Trypanozoon species remain unclear because the majority of phylogenetic analyses has been based on only a few genes. In this study, we have conducted a phylogenetic analysis based on genome-wide SNP analysis comprising 56 genomes from the Trypanozoon subgenus. Our data reveal that T. equiperdum has emerged at least once in Eastern Africa and T. evansi at two independent occasions in Western Africa. The genomes within the T. equiperdum and T. evansi monophyletic clusters show extremely little variation, probably due to the clonal spread linked to the independence from tsetse flies for their transmission. |
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AbstractList | Trypanosomes cause a variety of diseases in man and domestic animals in Africa, Latin America, and Asia. In the Trypanozoon subgenus, Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense cause human African trypanosomiasis, whereas Trypanosoma brucei brucei, Trypanosoma evansi, and Trypanosoma equiperdum are responsible for nagana, surra, and dourine in domestic animals, respectively. The genetic relationships between T. evansi and T. equiperdum and other Trypanozoon species remain unclear because the majority of phylogenetic analyses has been based on only a few genes. In this study, we have conducted a phylogenetic analysis based on genome-wide SNP analysis comprising 56 genomes from the Trypanozoon subgenus. Our data reveal that T. equiperdum has emerged at least once in Eastern Africa and T. evansi at two independent occasions in Western Africa. The genomes within the T. equiperdum and T. evansi monophyletic clusters show extremely little variation, probably due to the clonal spread linked to the independence from tsetse flies for their transmission. Trypanosomes cause a variety of diseases in man and domestic animals in Africa, Latin America, and Asia. In the Trypanozoon subgenus, Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense cause human African trypanosomiasis, whereas Trypanosoma brucei brucei , Trypanosoma evansi , and Trypanosoma equiperdum are responsible for nagana, surra, and dourine in domestic animals, respectively. The genetic relationships between T. evansi and T. equiperdum and other Trypanozoon species remain unclear because the majority of phylogenetic analyses has been based on only a few genes. In this study, we have conducted a phylogenetic analysis based on genome-wide SNP analysis comprising 56 genomes from the Trypanozoon subgenus. Our data reveal that T. equiperdum has emerged at least once in Eastern Africa and T. evansi at two independent occasions in Western Africa. The genomes within the T. equiperdum and T. evansi monophyletic clusters show extremely little variation, probably due to the clonal spread linked to the independence from tsetse flies for their transmission. |
Author | Wilkes, Jonathan M Deborggraeve, Stijn Van Reet, Nick Van den Broeck, Frederik Cuypers, Bart Dujardin, Jean-Claude Laukens, Kris Goddeeris, Bruno Büscher, Philippe Birhanu, Hadush Meehan, Conor J Claes, Filip Cauchard, Julien |
AuthorAffiliation | 7 College of Veterinary Medicine, Mekelle University, Tigray, Ethiopia 4 Wellcome Trust Centre of Molecular Parasitology, University of Glasgow, United Kingdom 8 Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium 2 Department of Mathematics and Computer Sciences, University of Antwerp, Belgium 5 Food and Agriculture Organization of the United Nations (FAO), Regional Office for Asia and the Pacific, Bangkok, Thailand 1 Biomedical Sciences Department, Institute of Tropical Medicine, Antwerp, Belgium 3 Anses Dozulé Laboratory for Equine Diseases, Goustranville, France 6 Faculty of Bioscience Engineering, KU Leuven, Belgium |
AuthorAffiliation_xml | – name: 1 Biomedical Sciences Department, Institute of Tropical Medicine, Antwerp, Belgium – name: 2 Department of Mathematics and Computer Sciences, University of Antwerp, Belgium – name: 4 Wellcome Trust Centre of Molecular Parasitology, University of Glasgow, United Kingdom – name: 3 Anses Dozulé Laboratory for Equine Diseases, Goustranville, France – name: 6 Faculty of Bioscience Engineering, KU Leuven, Belgium – name: 5 Food and Agriculture Organization of the United Nations (FAO), Regional Office for Asia and the Pacific, Bangkok, Thailand – name: 8 Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium – name: 7 College of Veterinary Medicine, Mekelle University, Tigray, Ethiopia |
Author_xml | – sequence: 1 givenname: Bart surname: Cuypers fullname: Cuypers, Bart organization: Department of Mathematics and Computer Sciences, University of Antwerp, Belgium – sequence: 2 givenname: Frederik surname: Van den Broeck fullname: Van den Broeck, Frederik organization: Biomedical Sciences Department, Institute of Tropical Medicine, Antwerp, Belgium – sequence: 3 givenname: Nick surname: Van Reet fullname: Van Reet, Nick organization: Biomedical Sciences Department, Institute of Tropical Medicine, Antwerp, Belgium – sequence: 4 givenname: Conor J surname: Meehan fullname: Meehan, Conor J organization: Biomedical Sciences Department, Institute of Tropical Medicine, Antwerp, Belgium – sequence: 5 givenname: Julien surname: Cauchard fullname: Cauchard, Julien organization: Anses Dozulé Laboratory for Equine Diseases, Goustranville, France – sequence: 6 givenname: Jonathan M surname: Wilkes fullname: Wilkes, Jonathan M organization: Wellcome Trust Centre of Molecular Parasitology, University of Glasgow, United Kingdom – sequence: 7 givenname: Filip surname: Claes fullname: Claes, Filip organization: Food and Agriculture Organization of the United Nations (FAO), Regional Office for Asia and the Pacific, Bangkok, Thailand – sequence: 8 givenname: Bruno surname: Goddeeris fullname: Goddeeris, Bruno organization: Faculty of Bioscience Engineering, KU Leuven, Belgium – sequence: 9 givenname: Hadush surname: Birhanu fullname: Birhanu, Hadush organization: College of Veterinary Medicine, Mekelle University, Tigray, Ethiopia – sequence: 10 givenname: Jean-Claude surname: Dujardin fullname: Dujardin, Jean-Claude organization: Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium – sequence: 11 givenname: Kris surname: Laukens fullname: Laukens, Kris organization: Department of Mathematics and Computer Sciences, University of Antwerp, Belgium – sequence: 12 givenname: Philippe surname: Büscher fullname: Büscher, Philippe organization: Biomedical Sciences Department, Institute of Tropical Medicine, Antwerp, Belgium – sequence: 13 givenname: Stijn surname: Deborggraeve fullname: Deborggraeve, Stijn organization: Biomedical Sciences Department, Institute of Tropical Medicine, Antwerp, Belgium |
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Keywords | Trypanosoma evansi Trypanozoon whole genome sequencing Trypansoma equiperdum phylogeny SNP analysis |
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Snippet | Trypanosomes cause a variety of diseases in man and domestic animals in Africa, Latin America, and Asia. In the Trypanozoon subgenus, Trypanosoma brucei... Trypanosomes cause a variety of diseases in man and domestic animals in Africa, Latin America, and Asia. In the Trypanozoon subgenus, Trypanosoma brucei... |
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SubjectTerms | Africa, Eastern Africa, Western Genes, Protozoan Genome, Protozoan Genome-Wide Association Study Phylogeny Polymorphism, Single Nucleotide Trypanosoma - genetics |
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Title | Genome-Wide SNP Analysis Reveals Distinct Origins of Trypanosoma evansi and Trypanosoma equiperdum |
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