Muscle α-adrenergic responsiveness during exercise and ATP-induced vasodilation in chronic obstructive pulmonary disease patients

• Published in: American journal of physiology. Heart and circulatory physiology Vol. 314; no. 2; pp. H180 - H187
• Main Authors: Iepsen, U. W., Munch, G. W., Ryrsø, C. K., Secher, N. H., Lange, P., Thaning, P., Pedersen, B. K., Mortensen, S. P.
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.02.2018
• Subjects: Adenosine triphosphate; Adenosine Triphosphate - administration & dosage; Age; Aged; Blood flow; Case-Control Studies; Chronic obstructive pulmonary disease; Conductance; Exercise; Female; Femoral Artery - drug effects; Femoral Artery - physiopathology; Femur; Humans; Infusions, Intra-Arterial; Knee; Leg; Lower Extremity - blood supply; Lung diseases; Male; Middle Aged; Muscles; Muscular system; Norepinephrine; Obstructive lung disease; Patients; Pulmonary Disease, Chronic Obstructive - diagnosis; Pulmonary Disease, Chronic Obstructive - metabolism; Pulmonary Disease, Chronic Obstructive - physiopathology; Quadriceps Muscle - blood supply; Quadriceps Muscle - metabolism; Receptors, Adrenergic, alpha - metabolism; Regional Blood Flow; Signal Transduction - drug effects; Sympathomimetics - administration & dosage; Tyramine; Tyramine - administration & dosage; Vasoconstriction; Vasoconstriction - drug effects; Vasodilation; Vasodilation - drug effects; Vasodilator Agents - administration & dosage; Veins & arteries; exercise; leg blood flow; functional sympatholysis

Sympathetic vasoconstriction is blunted in exercising muscle (functional sympatholysis) but becomes attenuated with age. We tested the hypothesis that functional sympatholysis is further impaired in chronic obstructive pulmonary disease (COPD) patients. We determined leg blood flow and calculated le...