Quantitative Susceptibility Mapping Suggests Altered Brain Iron in Premanifest Huntington Disease

• Published in: American journal of neuroradiology : AJNR Vol. 37; no. 5; pp. 789 - 796
• Main Authors: van Bergen, J. M. G., Hua, J., Unschuld, P. G., Lim, I. A. L., Jones, C. K., Margolis, R. L., Ross, C. A., van Zijl, P. C. M., Li, X.
• Format: Journal Article
• Language: English
• Published: United States American Society of Neuroradiology 01.05.2016
• Subjects: Adult; Adult Brain; Brain - diagnostic imaging; Brain - pathology; Disease Progression; Female; Functional; Gray Matter - diagnostic imaging; Gray Matter - pathology; Humans; Huntington Disease - diagnostic imaging; Huntington Disease - pathology; Iron - analysis; Magnetic Resonance Imaging - methods; Male; Middle Aged; Neuroimaging - methods

In patients with premanifest (nonsymptomatic) and advanced Huntington disease, changes in brain iron levels in the basal ganglia have been previously reported, especially in the striatum. Quantitative susceptibility mapping by using MR phase imaging allows in vivo measurements of tissue magnetic sus...