Interleukin-17 and Kidney Allograft Outcome

Abstract Acute rejection episodes (ARE) are important complications that involve the interplay between mechanisms that maintain graft tolerance and promote rejection. The proinflammatory cytokine interleukin-17 (IL-17) has been implicated in many conditions in humans and mice. In kidney transplant p...

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Published inTransplantation proceedings Vol. 41; no. 5; pp. 1562 - 1564
Main Authors Crispim, J.C.O, Grespan, R, Martelli-Palomino, G, Rassi, D.M, Costa, R.S, Saber, L.T, Cunha, F.Q, Donadi, E.A
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier Inc 01.06.2009
Elsevier
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Abstract Abstract Acute rejection episodes (ARE) are important complications that involve the interplay between mechanisms that maintain graft tolerance and promote rejection. The proinflammatory cytokine interleukin-17 (IL-17) has been implicated in many conditions in humans and mice. In kidney transplant patients, the evaluation IL-17 levels has been performed in only a few patients. We performed a cross-sectional study correlating quantitative IL-17 levels and clinical outcomes. Patients and methods We studied 19 specimens from biopsies performed in patients ( n = 19) who received isolated kidney grafts. ARE signs were present in 9 (47%) patients who provide specimens; whereas, 10 (53%) others showed no signs of rejection. Eighteen healthy control sample IL-17 underwent measurement, all of which were performed by an enzyme-linked immunosorbent assay method. We assessed other factors, such as the recipients demographic data, cold ischemia time, HLA mismatches, time elapsed from transplantation to the biopsy, posttransplantation status, antibody panel, donor type, and immunosuppressive treatment. Results IL-17 levels were clearly increased among samples derived from patients with ongoing rejection (125.7 ± 27.06 pg/mL) in contrast, to the nonrejection group, (30 ± 13.32 pg/mL) ( P < .05). Healthy controls showed no detectable IL-17 levels. Conclusions These findings suggested that IL-17 was important in the pathophysiology of acute kidney rejection.
AbstractList UNLABELLEDAcute rejection episodes (ARE) are important complications that involve the interplay between mechanisms that maintain graft tolerance and promote rejection. The proinflammatory cytokine interleukin-17 (IL-17) has been implicated in many conditions in humans and mice. In kidney transplant patients, the evaluation IL-17 levels has been performed in only a few patients. We performed a cross-sectional study correlating quantitative IL-17 levels and clinical outcomes.PATIENTS AND METHODSWe studied 19 specimens from biopsies performed in patients (n = 19) who received isolated kidney grafts. ARE signs were present in 9 (47%) patients who provide specimens; whereas, 10 (53%) others showed no signs of rejection. Eighteen healthy control sample IL-17 underwent measurement, all of which were performed by an enzyme-linked immunosorbent assay method. We assessed other factors, such as the recipients demographic data, cold ischemia time, HLA mismatches, time elapsed from transplantation to the biopsy, posttransplantation status, antibody panel, donor type, and immunosuppressive treatment.RESULTSIL-17 levels were clearly increased among samples derived from patients with ongoing rejection (125.7 +/- 27.06 pg/mL) in contrast, to the nonrejection group, (30 +/- 13.32 pg/mL) (P < .05). Healthy controls showed no detectable IL-17 levels.CONCLUSIONSThese findings suggested that IL-17 was important in the pathophysiology of acute kidney rejection.
Abstract Acute rejection episodes (ARE) are important complications that involve the interplay between mechanisms that maintain graft tolerance and promote rejection. The proinflammatory cytokine interleukin-17 (IL-17) has been implicated in many conditions in humans and mice. In kidney transplant patients, the evaluation IL-17 levels has been performed in only a few patients. We performed a cross-sectional study correlating quantitative IL-17 levels and clinical outcomes. Patients and methods We studied 19 specimens from biopsies performed in patients ( n = 19) who received isolated kidney grafts. ARE signs were present in 9 (47%) patients who provide specimens; whereas, 10 (53%) others showed no signs of rejection. Eighteen healthy control sample IL-17 underwent measurement, all of which were performed by an enzyme-linked immunosorbent assay method. We assessed other factors, such as the recipients demographic data, cold ischemia time, HLA mismatches, time elapsed from transplantation to the biopsy, posttransplantation status, antibody panel, donor type, and immunosuppressive treatment. Results IL-17 levels were clearly increased among samples derived from patients with ongoing rejection (125.7 ± 27.06 pg/mL) in contrast, to the nonrejection group, (30 ± 13.32 pg/mL) ( P < .05). Healthy controls showed no detectable IL-17 levels. Conclusions These findings suggested that IL-17 was important in the pathophysiology of acute kidney rejection.
Acute rejection episodes (ARE) are important complications that involve the interplay between mechanisms that maintain graft tolerance and promote rejection. The proinflammatory cytokine interleukin-17 (IL-17) has been implicated in many conditions in humans and mice. In kidney transplant patients, the evaluation IL-17 levels has been performed in only a few patients. We performed a cross-sectional study correlating quantitative IL-17 levels and clinical outcomes. We studied 19 specimens from biopsies performed in patients (n = 19) who received isolated kidney grafts. ARE signs were present in 9 (47%) patients who provide specimens; whereas, 10 (53%) others showed no signs of rejection. Eighteen healthy control sample IL-17 underwent measurement, all of which were performed by an enzyme-linked immunosorbent assay method. We assessed other factors, such as the recipients demographic data, cold ischemia time, HLA mismatches, time elapsed from transplantation to the biopsy, posttransplantation status, antibody panel, donor type, and immunosuppressive treatment. IL-17 levels were clearly increased among samples derived from patients with ongoing rejection (125.7 +/- 27.06 pg/mL) in contrast, to the nonrejection group, (30 +/- 13.32 pg/mL) (P < .05). Healthy controls showed no detectable IL-17 levels. These findings suggested that IL-17 was important in the pathophysiology of acute kidney rejection.
Acute rejection episodes (ARE) are important complications that involve the interplay between mechanisms that maintain graft tolerance and promote rejection. The proinflammatory cytokine interleukin-17 (IL-17) has been implicated in many conditions in humans and mice. In kidney transplant patients, the evaluation IL-17 levels has been performed in only a few patients. We performed a cross-sectional study correlating quantitative IL-17 levels and clinical outcomes. We studied 19 specimens from biopsies performed in patients ( n = 19) who received isolated kidney grafts. ARE signs were present in 9 (47%) patients who provide specimens; whereas, 10 (53%) others showed no signs of rejection. Eighteen healthy control sample IL-17 underwent measurement, all of which were performed by an enzyme-linked immunosorbent assay method. We assessed other factors, such as the recipients demographic data, cold ischemia time, HLA mismatches, time elapsed from transplantation to the biopsy, posttransplantation status, antibody panel, donor type, and immunosuppressive treatment. IL-17 levels were clearly increased among samples derived from patients with ongoing rejection (125.7 ± 27.06 pg/mL) in contrast, to the nonrejection group, (30 ± 13.32 pg/mL) ( P < .05). Healthy controls showed no detectable IL-17 levels. These findings suggested that IL-17 was important in the pathophysiology of acute kidney rejection.
Author Rassi, D.M
Crispim, J.C.O
Saber, L.T
Grespan, R
Donadi, E.A
Cunha, F.Q
Martelli-Palomino, G
Costa, R.S
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Cites_doi 10.4049/jimmunol.164.5.2832
10.1046/j.1523-1755.1999.00299.x
10.1016/S0041-1345(00)01382-8
10.1111/j.1432-2277.2001.tb00062.x
10.1159/000064106
10.1681/ASN.V981526
10.1038/ni1497
10.1681/ASN.V11112044
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Issue 5
Keywords Medicine
Prognosis
Treatment
Urinary system
Surgery
Evolution
Graft
Transplantation
Homotransplantation
Interleukin 17
Kidney
Language English
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References Kooten, Boontra, Paape (bib3) 1998; 19
Racusen, Solezz, Colvin (bib6) 1999; 55
Woltman, Haij, Boomtra (bib2) 2000; 11
De, Xavier, Sampaio (bib4) 2002; 92
Ziolkowska, Koc, Luszczykiewicz (bib5) 2000; 164
Loong, Lin, Lui (bib8) 2000; 32
Hsieh, Loong, Lui (bib7) 2001; 14
Wilson, Boniface, Chan (bib1) 2007; 8
Racusen (10.1016/j.transproceed.2009.01.092_bib6) 1999; 55
Ziolkowska (10.1016/j.transproceed.2009.01.092_bib5) 2000; 164
Loong (10.1016/j.transproceed.2009.01.092_bib8) 2000; 32
Woltman (10.1016/j.transproceed.2009.01.092_bib2) 2000; 11
Kooten (10.1016/j.transproceed.2009.01.092_bib3) 1998; 19
Hsieh (10.1016/j.transproceed.2009.01.092_bib7) 2001; 14
De (10.1016/j.transproceed.2009.01.092_bib4) 2002; 92
Wilson (10.1016/j.transproceed.2009.01.092_bib1) 2007; 8
References_xml – volume: 164
  start-page: 2832
  year: 2000
  ident: bib5
  article-title: High levels of IL-17 in rheumatoid arthritis patients: IL-15 triggers in vitro IL-17 production via cyclosporin A-sensitive mechanism
  publication-title: J Immunol
  contributor:
    fullname: Luszczykiewicz
– volume: 32
  start-page: 1773
  year: 2000
  ident: bib8
  article-title: Expression of interleukin-17 as a predictive parameter in acute renal allograft rejection
  publication-title: Transplant Proce
  contributor:
    fullname: Lui
– volume: 8
  start-page: 950
  year: 2007
  ident: bib1
  article-title: Development, cytokine profile and function of human interleukin 17-producing helper T cells
  publication-title: Nat Immunol
  contributor:
    fullname: Chan
– volume: 92
  start-page: 622
  year: 2002
  ident: bib4
  article-title: The synthesis by fine-nedle aspiration biopsy culture of IL-7, IL-16 and IL-18 is significantly associated with acute rejection in kidney transplants
  publication-title: Nephron
  contributor:
    fullname: Sampaio
– volume: 19
  start-page: 1526
  year: 1998
  ident: bib3
  article-title: Interleukin-17 activates human renal epithelial cells in vitro and is expressed during renal allograft rejection
  publication-title: J Am Soc Nephro
  contributor:
    fullname: Paape
– volume: 55
  start-page: 713
  year: 1999
  ident: bib6
  article-title: The Bannf 97 working classification of renal allograft pathology
  publication-title: Kidney Int
  contributor:
    fullname: Colvin
– volume: 11
  start-page: 2044
  year: 2000
  ident: bib2
  article-title: Interleukin-17 and CD40-ligand synergistically enhance cytokine and chomokine production by renal epithelial cells
  publication-title: J Am Nephrol
  contributor:
    fullname: Boomtra
– volume: 14
  start-page: 287
  year: 2001
  ident: bib7
  article-title: IL-17 expression as a possible predictive parameter for subclinical renal allograft rejection
  publication-title: Transpl Int
  contributor:
    fullname: Lui
– volume: 164
  start-page: 2832
  year: 2000
  ident: 10.1016/j.transproceed.2009.01.092_bib5
  article-title: High levels of IL-17 in rheumatoid arthritis patients: IL-15 triggers in vitro IL-17 production via cyclosporin A-sensitive mechanism
  publication-title: J Immunol
  doi: 10.4049/jimmunol.164.5.2832
  contributor:
    fullname: Ziolkowska
– volume: 55
  start-page: 713
  year: 1999
  ident: 10.1016/j.transproceed.2009.01.092_bib6
  article-title: The Bannf 97 working classification of renal allograft pathology
  publication-title: Kidney Int
  doi: 10.1046/j.1523-1755.1999.00299.x
  contributor:
    fullname: Racusen
– volume: 32
  start-page: 1773
  year: 2000
  ident: 10.1016/j.transproceed.2009.01.092_bib8
  article-title: Expression of interleukin-17 as a predictive parameter in acute renal allograft rejection
  publication-title: Transplant Proce
  doi: 10.1016/S0041-1345(00)01382-8
  contributor:
    fullname: Loong
– volume: 14
  start-page: 287
  year: 2001
  ident: 10.1016/j.transproceed.2009.01.092_bib7
  article-title: IL-17 expression as a possible predictive parameter for subclinical renal allograft rejection
  publication-title: Transpl Int
  doi: 10.1111/j.1432-2277.2001.tb00062.x
  contributor:
    fullname: Hsieh
– volume: 92
  start-page: 622
  year: 2002
  ident: 10.1016/j.transproceed.2009.01.092_bib4
  article-title: The synthesis by fine-nedle aspiration biopsy culture of IL-7, IL-16 and IL-18 is significantly associated with acute rejection in kidney transplants
  publication-title: Nephron
  doi: 10.1159/000064106
  contributor:
    fullname: De
– volume: 19
  start-page: 1526
  year: 1998
  ident: 10.1016/j.transproceed.2009.01.092_bib3
  article-title: Interleukin-17 activates human renal epithelial cells in vitro and is expressed during renal allograft rejection
  publication-title: J Am Soc Nephro
  doi: 10.1681/ASN.V981526
  contributor:
    fullname: Kooten
– volume: 8
  start-page: 950
  year: 2007
  ident: 10.1016/j.transproceed.2009.01.092_bib1
  article-title: Development, cytokine profile and function of human interleukin 17-producing helper T cells
  publication-title: Nat Immunol
  doi: 10.1038/ni1497
  contributor:
    fullname: Wilson
– volume: 11
  start-page: 2044
  year: 2000
  ident: 10.1016/j.transproceed.2009.01.092_bib2
  article-title: Interleukin-17 and CD40-ligand synergistically enhance cytokine and chomokine production by renal epithelial cells
  publication-title: J Am Nephrol
  doi: 10.1681/ASN.V11112044
  contributor:
    fullname: Woltman
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Snippet Abstract Acute rejection episodes (ARE) are important complications that involve the interplay between mechanisms that maintain graft tolerance and promote...
Acute rejection episodes (ARE) are important complications that involve the interplay between mechanisms that maintain graft tolerance and promote rejection....
UNLABELLEDAcute rejection episodes (ARE) are important complications that involve the interplay between mechanisms that maintain graft tolerance and promote...
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SubjectTerms Adult
Animals
Biological and medical sciences
Biomarkers - blood
Biopsy
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Graft Rejection - blood
Graft Rejection - immunology
Humans
Immunosuppressive Agents - therapeutic use
Interleukin-17 - blood
Male
Medical sciences
Mice
Middle Aged
Reference Values
Surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Tissue, organ and graft immunology
Title Interleukin-17 and Kidney Allograft Outcome
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https://dx.doi.org/10.1016/j.transproceed.2009.01.092
https://www.ncbi.nlm.nih.gov/pubmed/19545679
https://search.proquest.com/docview/67409572
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