Prognostic Role of Circulating miRNAs in Early-Stage Non-Small Cell Lung Cancer

Non-small cell lung cancer (NSCLC) is the primary cause of cancer-related death worldwide, with a low 5-year survival rate even in fully resected early-stage disease. Novel biomarkers to identify patients at higher risk of relapse are needed. We studied the prognostic value of 84 circulating microRN...

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Published inJournal of clinical medicine Vol. 8; no. 2; p. 131
Main Authors Ulivi, Paola, Petracci, Elisabetta, Marisi, Giorgia, Baglivo, Sara, Chiari, Rita, Billi, Monia, Canale, Matteo, Pasini, Luigi, Racanicchi, Serena, Vagheggini, Alessandro, Delmonte, Angelo, Mariotti, Marita, Ludovini, Vienna, Bonafè, Massimiliano, Crinò, Lucio, Grignani, Francesco
Format Journal Article
LanguageEnglish
Published Switzerland MDPI 23.01.2019
Subjects
miRNAs
early-stage NSCLC
plasma
prognosis
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Abstract Non-small cell lung cancer (NSCLC) is the primary cause of cancer-related death worldwide, with a low 5-year survival rate even in fully resected early-stage disease. Novel biomarkers to identify patients at higher risk of relapse are needed. We studied the prognostic value of 84 circulating microRNAs (miRNAs) in 182 patients with resected early-stage NSCLC (99 adenocarcinoma (ADC), 83 squamous cell carcinoma (SCC)) from whom peripheral blood samples were collected pre-surgery. miRNA expression was analyzed in relation to disease-free survival (DFS) and overall survival (OS). In univariable analyses, five miRNAs (miR-26a-5p, miR-126-3p, miR-130b-3p, miR-205-5p, and miR-21-5p) were significantly associated with DFS in SCC, and four (miR-130b-3p, miR-26a-5p, miR-126-3p, and miR-205-5p) remained significantly associated with OS. In ADC, miR-222-3p, miR-22-3p, and mir-93-5p were significantly associated with DFS, miR-22-3p remaining significant for OS. Given the high-dimensionality of the dataset, multivariable models were obtained using a regularized Cox regression including all miRNAs and clinical covariates. After adjustment for disease stage, only miR-126-3p showed an independent prognostic role, with higher values associated with longer DFS in SCC patients. With regard to ADC and OS, no miRNA remained significant in multivariable analysis. Further investigation into the role of miR-126 as a prognostic marker in early-stage NSCLC is warranted.
AbstractList Non-small cell lung cancer (NSCLC) is the primary cause of cancer-related death worldwide, with a low 5-year survival rate even in fully resected early-stage disease. Novel biomarkers to identify patients at higher risk of relapse are needed. We studied the prognostic value of 84 circulating microRNAs (miRNAs) in 182 patients with resected early-stage NSCLC (99 adenocarcinoma (ADC), 83 squamous cell carcinoma (SCC)) from whom peripheral blood samples were collected pre-surgery. miRNA expression was analyzed in relation to disease-free survival (DFS) and overall survival (OS). In univariable analyses, five miRNAs (miR-26a-5p, miR-126-3p, miR-130b-3p, miR-205-5p, and miR-21-5p) were significantly associated with DFS in SCC, and four (miR-130b-3p, miR-26a-5p, miR-126-3p, and miR-205-5p) remained significantly associated with OS. In ADC, miR-222-3p, miR-22-3p, and mir-93-5p were significantly associated with DFS, miR-22-3p remaining significant for OS. Given the high-dimensionality of the dataset, multivariable models were obtained using a regularized Cox regression including all miRNAs and clinical covariates. After adjustment for disease stage, only miR-126-3p showed an independent prognostic role, with higher values associated with longer DFS in SCC patients. With regard to ADC and OS, no miRNA remained significant in multivariable analysis. Further investigation into the role of miR-126 as a prognostic marker in early-stage NSCLC is warranted.
Author Billi, Monia
Mariotti, Marita
Crinò, Lucio
Ulivi, Paola
Petracci, Elisabetta
Grignani, Francesco
Baglivo, Sara
Bonafè, Massimiliano
Chiari, Rita
Canale, Matteo
Racanicchi, Serena
Ludovini, Vienna
Delmonte, Angelo
Vagheggini, Alessandro
Marisi, Giorgia
Pasini, Luigi
AuthorAffiliation 1 Biosciences Laboratory, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, 47014 Meldola, Italy; giorgia.marisi@irst.emr.it (G.M.); matteo.canale@irst.emr.it (M.C.); luigi.pasini@irst.emr.it (L.P.); massimiliano.bonafe@irst.emr.it (M.B.)
5 Department of Medical Oncology, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, 47014 Meldola, Italy; angelo.delmonte@irst.emr.it (A.D.); marita.mariotti@irst.emr.it (M.M.); lucio.crino@irst.emr.it (L.C.)
2 Biostatistics and Clinical Trials Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, 47014 Meldola, Italy; elisabetta.petracci@irst.emr.it (E.P.); alessandro.vagheggin@irst.emr.it (A.V.)
4 General Pathology Unit, Department of Medicine, University of Perugia, 06132 Perugia, Italy; monia.billi@unipg.it (M.B.); serena.racanicchi@unipg.it (S.R.); francesco.grignani@unipg.it (F.G.)
3 Department of Medical Oncology, Santa Maria della Misericordia Hospital, Azi
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Issue 2
Keywords miRNAs
early-stage NSCLC
plasma
prognosis
Language English
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Title Prognostic Role of Circulating miRNAs in Early-Stage Non-Small Cell Lung Cancer
URI https://www.ncbi.nlm.nih.gov/pubmed/30678026
https://search.proquest.com/docview/2179443150
https://pubmed.ncbi.nlm.nih.gov/PMC6407000
Volume 8
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