The atypical RNA-binding protein Taf15 regulates dorsoanterior neural development through diverse mechanisms in Xenopus tropicalis

• Published in: Development (Cambridge) Vol. 148; no. 15
• Main Authors: DeJong, Caitlin S., Dichmann, Darwin S., Exner, Cameron R. T., Xu, Yuxiao, Harland, Richard M.
• Format: Journal Article
• Language: English
• Published: England The Company of Biologists Ltd 01.08.2021
• Subjects: Animals; Brain - metabolism; Brain - physiology; Cell Differentiation - physiology; Exons - physiology; Female; Male; Neural Development; Neurogenesis - physiology; Neurons - metabolism; Neurons - physiology; RNA-Binding Proteins - metabolism; TATA-Binding Protein Associated Factors - metabolism; Xenopus - metabolism; Xenopus - physiology; Xenopus; Maternal deposition; RNA-seq; Embryo development; FET proteins; Transcript regulation

The FET family of atypical RNA-binding proteins includes Fused in sarcoma (FUS), Ewing's sarcoma (EWS) and the TATA-binding protein-associate factor 15 (TAF15). FET proteins are highly conserved, suggesting specialized requirements for each protein. Fus regulates splicing of transcripts require...