Twenty years of progress in angiotensin converting enzyme 2 and its link to SARS-CoV-2 disease

• Published in: Clinical science (1979) Vol. 134; no. 19; pp. 2645 - 2664
• Main Authors: Ferrario, Carlos M., Ahmad, Sarfaraz, Groban, Leanne
• Format: Journal Article
• Language: English
• Published: England 16.10.2020
• Subjects: Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors - pharmacology; Betacoronavirus - pathogenicity; Coronavirus Infections - drug therapy; Coronavirus Infections - enzymology; Coronavirus Infections - virology; COVID-19; Humans; Pandemics; Peptidyl-Dipeptidase A - drug effects; Peptidyl-Dipeptidase A - metabolism; Pneumonia, Viral - drug therapy; Pneumonia, Viral - enzymology; Pneumonia, Viral - virology; SARS-CoV-2; Time Factors; cardiovascular disease; angiotensin-(1-7); coronavirus; innate immunity; angiotensin II; chymase

The virulence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the aggressive nature of the disease has transformed the universal pace of research in the desperate attempt to seek effective therapies to halt the morbidity and mortality of this pandemic. The rapid seq...