PTEN interacts with the transcription machinery on chromatin and regulates RNA polymerase II-mediated transcription

• Published in: Nucleic acids research Vol. 47; no. 11; pp. 5573 - 5586
• Main Authors: Steinbach, Nicole, Hasson, Dan, Mathur, Deepti, Stratikopoulos, Elias E, Sachidanandam, Ravi, Bernstein, Emily, Parsons, Ramon E
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 20.06.2019
• Subjects: Animals; Cell Line; Cells, Cultured; Chromatin - genetics; Chromatin - metabolism; Gene regulation, Chromatin and Epigenetics; HEK293 Cells; HeLa Cells; Humans; Mice, Inbred C57BL; Mice, Knockout; Promoter Regions, Genetic - genetics; Protein Binding; PTEN Phosphohydrolase - genetics; PTEN Phosphohydrolase - metabolism; RNA Polymerase II - genetics; RNA Polymerase II - metabolism; Signal Transduction - genetics; Transcription, Genetic; Transcriptional Elongation Factors - genetics; Transcriptional Elongation Factors - metabolism

Regulation of RNA polymerase II (RNAPII)-mediated transcription controls cellular phenotypes such as cancer. Phosphatase and tensin homologue deleted on chromosome ten (PTEN), one of the most commonly altered tumor suppressors in cancer, affects transcription via its role in antagonizing the PI3K/AK...