Cortical demyelination in PML and MS: Similarities and differences

• Published in: Neurology Vol. 70; no. 5; p. 336
• Main Authors: Moll, N M, Rietsch, A M, Ransohoff, A J, Cossoy, M B, Huang, D, Eichler, F S, Trapp, B D, Ransohoff, Richard M
• Format: Journal Article
• Language: English
• Published: United States 29.01.2008
• Subjects: Adult; Aged; AIDS Dementia Complex - pathology; Cell Count; Cerebral Cortex - pathology; Disease Progression; Female; Humans; Immunohistochemistry; JC Virus - isolation & purification; Leukoencephalopathy, Progressive Multifocal - pathology; Leukoencephalopathy, Progressive Multifocal - virology; Lymphocytes - pathology; Macrophages - pathology; Male; Microglia - pathology; Middle Aged; Multiple Sclerosis - pathology; Nerve Fibers, Myelinated - pathology; Neurites - pathology; Neurons - pathology
• ISSN: 1526-632X
• DOI: 10.1212/01.wnl.0000284601.54436.e4

To characterize pathologic changes in the cerebral cortex of patients with multiple sclerosis (MS) and progressive multifocal leukoencephalopathy (PML). Autopsy brain tissue was obtained from 13 patients with PML, 4 patients with MS, 2 patients with HIV encephalopathy, and 1 subject without neurolog...