Neurobehavioral effects of acute exposure to aromatic hydrocarbons

• Published in: International journal of toxicology Vol. 29; no. 3; p. 277
• Main Authors: McKee, Richard H, Lammers, J H C M, Muijser, H, Owen, D E, Kulig, B M
• Format: Journal Article
• Language: English
• Published: United States 01.05.2010
• Subjects: Animals; Arousal - drug effects; Benzene Derivatives - administration & dosage; Benzene Derivatives - metabolism; Benzene Derivatives - pharmacokinetics; Benzene Derivatives - toxicity; Body Temperature Regulation - drug effects; Body Weight - drug effects; Brain - drug effects; Brain - metabolism; Central Nervous System - drug effects; Convulsants - administration & dosage; Convulsants - metabolism; Convulsants - pharmacokinetics; Convulsants - toxicity; Dose-Response Relationship, Drug; Gait - drug effects; Hydrocarbons, Aromatic - administration & dosage; Hydrocarbons, Aromatic - metabolism; Hydrocarbons, Aromatic - pharmacokinetics; Hydrocarbons, Aromatic - toxicity; Inhalation Exposure - adverse effects; Male; Motor Activity - drug effects; Neuromuscular Agents - administration & dosage; Neuromuscular Agents - metabolism; Neuromuscular Agents - pharmacokinetics; Neuromuscular Agents - toxicity; Random Allocation; Rats; Rats, Wistar; Respiratory System - drug effects; Solvents - administration & dosage; Solvents - metabolism; Solvents - pharmacokinetics; Solvents - toxicity; Time Factors; Visual Perception - drug effects

This article reports the results of neurobehavioral tests on representative aromatic constituents, specifically C(9) to C(11) species. The testing evaluated effects in several domains including clinical effects, motor activity, functional observations, and visual discrimination performance. Exposure...