Pentapeptide Commonality Between Corynebacterium Diphtheriae Toxin and the Homo Sapiens Proteome

• Published in: Immunotherapy Vol. 3; no. 1; pp. 49 - 58
• Main Authors: Bavaro, Simona Lucia, Kanduc, Darja
• Format: Journal Article
• Language: English
• Published: England Future Medicine Ltd 01.01.2011
• Subjects: Amino Acid Sequence; Amino acids; Autoimmune diseases; Cross Reactions; Diphtheria; Diphtheria toxin; Diphtheria Toxin - chemistry; Diphtheria Toxin - immunology; Health aspects; Human subjects; Humans; Immunotherapy; Immunotherapy - methods; Molecular Sequence Data; Peptides - analysis; Peptides - immunology; Proteins; Proteins - chemistry; Proteins - immunology; Proteome; Risk factors; Tetanus; Italy
• ISSN: 1750-743X; 1750-7448
• DOI: 10.2217/imt.10.83

Cross-reactivity may affect diagnostic tests and cause harmful autoimmune reactions following immunotherapy. To predict potential cross-reactivity and search for safe immunotherapeutic approaches, we analyzed sequence identity between microbial antigens and the human proteome. Using diphtheria toxin...