Nascent RNA sequencing reveals mechanisms of gene regulation in the human malaria parasite Plasmodium falciparum

• Published in: Nucleic acids research Vol. 45; no. 13; pp. 7825 - 7840
• Main Authors: Lu, Xueqing Maggie, Batugedara, Gayani, Lee, Michael, Prudhomme, Jacques, Bunnik, Evelien M., Le Roch, Karine G.
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 27.07.2017
• Subjects: Animals; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genes, Protozoan; Genomics; Humans; Malaria, Falciparum - blood; Malaria, Falciparum - parasitology; Plasmodium falciparum - genetics; Plasmodium falciparum - growth & development; Plasmodium falciparum - pathogenicity; Promoter Regions, Genetic; RNA Polymerase II - metabolism; RNA, Messenger - genetics; RNA, Messenger - metabolism; RNA, Protozoan - genetics; RNA, Protozoan - metabolism; Sequence Analysis, RNA; Transcription, Genetic

Gene expression in Plasmodium falciparum is tightly regulated to ensure successful propagation of the parasite throughout its complex life cycle. The earliest transcriptomics studies in P. falciparum suggested a cascade of transcriptional activity over the course of the 48-hour intraerythrocytic dev...