Single-cell analysis reveals CD34+CD90+ endothelial cells promote tumor metastasis in gallbladder cancer

• Published in: NPJ precision oncology Vol. 9; no. 1; pp. 242 - 12
• Main Authors: Hou, Minghui, Chen, Jianan, Jiang, Youhai, Liu, Chunliang, Wang, Xiang, Liu, Erdong, Zong, Yali, Gu, Mingye, Meng, Zhengyuan, Wang, Senyan, Wei, Wenjuan, Liu, Qi, Wang, Hongyang, Fu, Jing, Zhao, Xiaofang
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 18.07.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 692/699/67/322; 692/699/67/327; Cancer Research; Cell growth; Extracellular matrix; Flow cytometry; Gallbladder cancer; Gene Therapy; Genes; Human Genetics; Immunoglobulins; Internal Medicine; Medical prognosis; Medicine; Medicine & Public Health; Metastasis; Oncology; Patients; Survival analysis; Vascular endothelial growth factor

Gallbladder cancer (GBC) is the most common malignancy of the biliary tract, with high metastasis incidence and extremely low survival rate. The tumor endothelial cells (TECs) are fundamental components in the tumor microenvironment and significantly contribute to various tumor progression; however,...