Short- and long-term effects of oral vancomycin on the human intestinal microbiota

• Published in: Journal of antimicrobial chemotherapy Vol. 72; no. 1; pp. 128 - 136
• Main Authors: Isaac, Sandrine, Scher, Jose U., Djukovic, Ana, Jiménez, Nuria, Littman, Dan R., Abramson, Steven B., Pamer, Eric G., Ubeda, Carles
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.01.2017
• Subjects: Administration, Oral; Animals; Anti-Bacterial Agents - administration & dosage; Feces - microbiology; Gastrointestinal Microbiome - drug effects; High-Throughput Nucleotide Sequencing; Humans; Metagenomics - methods; Mice; Microbiota - drug effects; Models, Animal; Original Research; Time; Vancomycin - administration & dosage

Oral vancomycin remains the mainstay of therapy for severe infections produced by Clostridium difficile, the most prevalent cause of healthcare-associated infectious diarrhoea in developed countries. However, its short- and long-term effects on the human intestinal microbiota remain largely unknown....