Study of cerebrovascular reactivity to hypercapnia by imaging photoplethysmography to develop a method for intraoperative assessment of the brain functional reserve
Intraoperative assessment of cerebrovascular reactivity is a relevant problem of neurosurgery. To assess the functional reserve of cerebral blood flow, we suggest using imaging photoplethysmography for measuring changes in cortical perfusion caused by CO inhalation. Feasibility of the technique was...
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Published in | Biomedical optics express Vol. 13; no. 1; pp. 184 - 196 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Optical Society of America
01.01.2022
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Online Access | Get full text |
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Summary: | Intraoperative assessment of cerebrovascular reactivity is a relevant problem of neurosurgery. To assess the functional reserve of cerebral blood flow, we suggest using imaging photoplethysmography for measuring changes in cortical perfusion caused by CO
inhalation. Feasibility of the technique was demonstrated in three groups of anesthetized rats (
=21) with opened and closed cranial windows. Our study for the first time revealed that the hemodynamic response to hypercapnia strongly depends on the cranial state. However, it was shown that regardless of the direction of changes in local and systemic hemodynamics, the ratio of normalized changes in arterial blood pressure and cortical perfusion could be used as a measure of the cerebrovascular functional reserve. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 2156-7085 2156-7085 |
DOI: | 10.1364/BOE.443477 |