An Investigation of Oxidative DNA Damage in Pharmacy Technicians Exposed to Antineoplastic Drugs in Two Chinese Hospitals Using The Urinary 8-OHdG Assay

• Published in: Biomedical and environmental sciences Vol. 25; no. 1; pp. 109 - 116
• Main Authors: HUANG, Yu Wen, JIAN, Le, ZHANG, Mei Bian, ZHOU, Quan, YAN, Xiao Feng, HUA, Xu Dong, ZHOU, Ying, HE, Ji Liang
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 01.02.2012; The Second Affiliated Hospital of College of Medicine of Zhejiang University, Hangzhou 310009, Zhejiang, China%School of Public Health, Curtin Health Innovation Research Institute, Curtin University of Technology, Perth 6845,Australia%Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, Zhejiang, China%Sir Run Run Shaw Hospital of College of Medicine of Zhejiang University, Hangzhou 310020, Zhejiang, China%Zhejiang Provincial Hospital of Traditional Chinese Medicine, Hangzhou 310012, Zhejiang, China%Zhejiang University, Medical College, Institute of Environmental Medicine, Hangzhou 310058, Zhejiang, China
• Subjects: Adult; air; Air - analysis; Antineoplastic Agents - analysis; Antineoplastic Agents - toxicity; Antineoplastic drugs; biomarkers; Case-Control Studies; China; chromium; Deoxyguanosine - analogs & derivatives; Deoxyguanosine - urine; DNA Damage; DNA氧化损伤; Female; fluorouracil; Fluorouracil - analysis; Fluorouracil - toxicity; gloves; Gloves, Protective; Health Personnel - statistics & numerical data; hospitals; Hospitals - statistics & numerical data; Humans; intravenous injection; Male; Masks; Occupational exposure; Occupational Exposure - statistics & numerical data; Oxidative DNA damage; Oxidative Stress; Pharmacy Intravenous Admixture Service; technicians; Urinary 8-OHdG; Young Adult; 个人防护装备; 中国; 医院; 尿; 技术员; 抗肿瘤药物; 药剂; China; Pharmacy Intravenous Admixture Service; Antineoplastic drugs; Urinary 8-OHdG; Occupational exposure; Oxidative DNA damage

Objective To investigate oxidative DNA damage in pharmacy technicians preparing antineoplastic drugs at the PIVAS （Pharmacy Intravenous Admixture Service） in two Chinese hospitals. Methods Urinary 8-OHdG served as a biomarker. 5-Fluorouracil （5-FU） concentrations in air, masks and gloves were determ...