Global, asynchronous partial sweeps at multiple insecticide resistance genes in Aedes mosquitoes

• Published in: Nature communications Vol. 15; no. 1; pp. 6251 - 19
• Main Authors: Schmidt, Thomas L, Endersby-Harshman, Nancy M, van Rooyen, Anthony R J, Katusele, Michelle, Vinit, Rebecca, Robinson, Leanne J, Laman, Moses, Karl, Stephan, Hoffmann, Ary A
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 24.07.2024; Nature Publishing Group UK; Nature Portfolio
• Subjects: Aedes - drug effects; Aedes - genetics; Aedes aegypti; Aedes albopictus; Animals; Aquatic insects; Chromosome 2; Chromosome 3; Chromosomes; Copy number; Culicidae; DNA Copy Number Variations; Evolution; Evolutionary genetics; Genes; Genetic diversity; Geographical distribution; Glutathione; Glutathione transferase; Glutathione Transferase - genetics; Glutathione Transferase - metabolism; Insect Proteins - genetics; Insect Proteins - metabolism; Insecticide resistance; Insecticide Resistance - genetics; Insecticides; Insecticides - pharmacology; Invasive species; Mosquito Vectors - drug effects; Mosquito Vectors - genetics; Mosquitoes; Nucleotides; Pesticide resistance; Pests; Phenotypes; Population genetics; Population studies; Populations; Sodium channels (voltage-gated); Vector-borne diseases; Voltage-Gated Sodium Channels - genetics; Yellow fever

Aedes aegypti (yellow fever mosquito) and Ae. albopictus (Asian tiger mosquito) are globally invasive pests that confer the world's dengue burden. Insecticide-based management has led to the evolution of insecticide resistance in both species, though the genetic architecture and geographical sp...