The autophagy-lysosome pathway: a potential target in the chemical and gene therapeutic strategies for Parkinson's disease

• Published in: Neural regeneration research Vol. 20; no. 1; pp. 139 - 158
• Main Authors: Jiao, Fengjuan, Meng, Lingyan, Du, Kang, Li, Xuezhi
• Format: Journal Article
• Language: English
• Published: India Medknow Publications & Media Pvt. Ltd 01.01.2025; Wolters Kluwer - Medknow; Wolters Kluwer Medknow Publications
• Subjects: autophagy; chemical therapy; gene therapy; parkinson’s disease; Review; α-synuclein

Parkinson's disease is a common neurodegenerative disease with movement disorders associated with the intracytoplasmic deposition of aggregate proteins such as α-synuclein in neurons. As one of the major intracellular degradation pathways, the autophagy-lysosome pathway plays an important role...