HSPB1 Gene Variants and Schizophrenia: A Case-Control Study in a Polish Population

• Published in: Disease markers Vol. 2022; pp. 1 - 9
• Main Authors: Kowalczyk, Malgorzata, Kucia, Krzysztof, Owczarek, Aleksander, Suchanek-Raif, Renata, Paul-Samojedny, Monika, Choreza, Piotr, Kowalski, Jan
• Format: Journal Article
• Language: English
• Published: United States Hindawi 15.03.2022; John Wiley & Sons, Inc
• Subjects: Age; Alzheimer's disease; Blood & organ donations; Case-Control Studies; Central nervous system; Emotional behavior; Family medical history; Gene expression; Genetic Predisposition to Disease; Genomes; Genotype; Genotypes; Haplotypes; Heat shock proteins; HSP27 Heat-Shock Proteins - genetics; Hsp27 protein; Humans; Ischemia; Mental disorders; Mental health; Molecular Chaperones - genetics; Neuroprotection; Patients; Poland - epidemiology; Polymorphism, Single Nucleotide; Population; Population studies; Schizophrenia; Schizophrenia - epidemiology; Schizophrenia - genetics; Single-nucleotide polymorphism; Suicides & suicide attempts; Poland

Schizophrenia (SCZ) is a severe psychiatric disorder that has a significant genetic component. HSPB1 (HSP27) is known for its neuroprotective functions under stress conditions and appears to play an important role during the development of the central nervous system, which is in agreement with the n...