Statin-associated immune-mediated necrotizing myopathy in Hispanic Americans

• Published in: Seminars in arthritis and rheumatism Vol. 73; p. 152759
• Main Authors: Dinh, Tam N., Nunez, Sharon E., Gonzales, Kristin M., Tapia, Krystle L., Garcia, Eric B., Fields, Roderick A., Muruganandam, Maheswari, Emil, N. Suzanne, O’Sullivan, Frank X., Sibbitt, Wilmer L.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2025
• Subjects: Adult; Aged; Autoantibodies - blood; Autoantibodies - immunology; Female; Hispanic; Hispanic or Latino; Humans; Hydroxymethylglutaryl CoA Reductases - immunology; Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects; Male; Middle Aged; Myopathy; Myositis; Myositis - chemically induced; Myositis - epidemiology; Myositis - ethnology; Myositis - immunology; Prevalence; Retrospective Studies; Statin; White; Myositis; Statin; Hispanic; Myopathy

•Pre-existing diabetes mellitus is more common in both Hispanics and Non-Hispanics with idiopathic inflammatory myopathies (IIM) in the Southwestern USA.•Hispanics have markedly increased statin-induced anti-HMGCR antibody immune-mediated necrotizing myopathy (IMNM) compared to Non-Hispanics.•Hispan...