Novel differences in renal gene expression in a diet-induced obesity model

• Published in: American journal of physiology. Renal physiology Vol. 314; no. 4; pp. F517 - F530
• Main Authors: Halperin Kuhns, Victoria L, Pluznick, Jennifer L
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.04.2018
• Subjects: Animals; Body weight gain; Cortex (somatosensory); Diet; Diet, High-Fat; Disease Models, Animal; End-stage renal disease; Female; Gene expression; Gene Expression Profiling - methods; Gene Expression Regulation; High fat diet; Kidney Cortex - metabolism; Kidney Cortex - pathology; Kidney diseases; Kidney Diseases - etiology; Kidney Diseases - genetics; Kidney Diseases - metabolism; Kidney Diseases - pathology; Kidneys; Liver; Male; Mice, Inbred C57BL; Obesity; Obesity - etiology; Obesity - genetics; Obesity - metabolism; Obesity - pathology; Polymerase Chain Reaction; Proteins; Renal cortex; Ribonucleic acid; RNA; Sex Factors; Time Factors; Transcription; Transcriptome; obesity-related kidney disease; RNA-Seq; sex differences; high-fat diet

Obesity is a significant risk factor for both chronic kidney disease and end-stage renal disease. To better understand disease development, we sought to identify novel genes differentially expressed early in disease progression. We first confirmed that mice fed a high-fat (HF) diet exhibit early sig...