Regional Cerebral Blood Flow during Wakeful Rest in Older Subjects with Mild to Severe Obstructive Sleep Apnea

• Published in: Sleep (New York, N.Y.) Vol. 38; no. 9; pp. 1439 - 1449
• Main Authors: Baril, Andrée-Ann, Gagnon, Katia, Arbour, Caroline, Soucy, Jean-Paul, Montplaisir, Jacques, Gagnon, Jean-François, Gosselin, Nadia
• Format: Journal Article
• Language: English
• Published: United States Associated Professional Sleep Societies, LLC 01.09.2015
• Subjects: Aged; Aged, 80 and over; Cerebral Cortex - blood supply; Cerebral Cortex - physiopathology; Cerebrovascular Circulation - physiology; Cognition Disorders - physiopathology; Female; Humans; Male; Middle Aged; Rest - physiology; Sleep Apnea, Obstructive - physiopathology; Sleep Deprivation - physiopathology; Sleep Stages - physiology; Tomography, Emission-Computed, Single-Photon; Wakefulness - physiology; Waking Cerebral Blood Flow in Older Subjects with Mild to Severe OSA; obstructive sleep apnea; cerebral perfusion; snoring; regional cerebral blood flow; aging; SPECT; neuroimaging

To evaluate changes in regional cerebral blood flow (rCBF) during wakeful rest in older subjects with mild to severe obstructive sleep apnea (OSA) and healthy controls, and to identify markers of OSA severity that predict altered rCBF. High-resolution (99m)Tc-HMPAO SPECT imaging during wakeful rest....