Uptake, distribution, and metabolism of trivalent arsenic in the pregnant mouse

• Published in: Journal of toxicology and environmental health Vol. 25; no. 4; p. 423
• Main Authors: Hood, R D, Vedel, G C, Zaworotko, M J, Tatum, F M, Meeks, R G
• Format: Journal Article
• Language: English
• Published: United States 01.12.1988
• Subjects: Animals; Arsenic - metabolism; Arsenic - pharmacokinetics; Arsenicals - metabolism; Arsenites; Female; Fetus - metabolism; Mice; Pregnancy; Teratogens - metabolism; Tissue Distribution

To investigate the distribution of trivalent arsenic (arsenite) in the pregnant rodent, CD-1 mice were dosed with sodium arsenite by ip injection or by gavage on gestation d 18 (copulation plug day = d 1). Doses were 8 (ip) or 25 (po) mg/kg, and samples of maternal blood, liver, and kidneys, as well...