Discovering sequence and structure landscapes in RNA interaction motifs

• Published in: Nucleic acids research Vol. 47; no. 10; pp. 4958 - 4969
• Main Authors: Adinolfi, Marta, Pietrosanto, Marco, Parca, Luca, Ausiello, Gabriele, Ferrè, Fabrizio, Helmer-Citterich, Manuela
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 04.06.2019
• Subjects: Algorithms; Animals; Base Sequence; Binding Sites; Cell Line; Computational Biology; HEK293 Cells; Hep G2 Cells; Humans; K562 Cells; Mice; MicroRNAs - chemistry; MicroRNAs - genetics; MicroRNAs - metabolism; Nucleotide Motifs; Protein Binding; RNA - chemistry; RNA - genetics; RNA - metabolism; RNA-Binding Proteins - chemistry; RNA-Binding Proteins - genetics; RNA-Binding Proteins - metabolism; Sequence Analysis, RNA - methods

RNA molecules are able to bind proteins, DNA and other small or long RNAs using information at primary, secondary or tertiary structure level. Recent techniques that use cross-linking and immunoprecipitation of RNAs can detect these interactions and, if followed by high-throughput sequencing, molecu...