HMGB1-Induced p62 Overexpression Promotes Snail-Mediated Epithelial-Mesenchymal Transition in Glioblastoma Cells via the Degradation of GSK-3β

• Published in: Theranostics Vol. 9; no. 7; pp. 1909 - 1922
• Main Authors: Li, Hong, Li, Junjie, Zhang, Guozhong, Da, Qian, Chen, Lei, Yu, Shishi, Zhou, Qiang, Weng, Zhijian, Xin, Zong, Shi, Linyong, Ma, Liyi, Huang, Annie, Qi, Songtao, Lu, Yuntao
• Format: Journal Article
• Language: English
• Published: Australia Ivyspring International Publisher 01.01.2019
• Subjects: Cell Line; Cell Line, Tumor; Cell Movement - physiology; Epithelial-Mesenchymal Transition - physiology; Glioblastoma - metabolism; Glioma - metabolism; Glycogen Synthase Kinase 3 beta - metabolism; HEK293 Cells; HMGB1 Protein - metabolism; Humans; Proteasome Endopeptidase Complex - metabolism; Research Paper; Sequestosome-1 Protein - metabolism; Signal Transduction - physiology; Snail Family Transcription Factors - metabolism; Transcription Factors - metabolism; GSK-3β; glioblastoma; HMGB1; epithelial-to-mesenchymal transition (EMT); p62

Glioblastoma (GBM) is the most common and aggressive brain tumor, characterized by its propensity to invade the surrounding brain parenchyma. The effect of extracellular high-mobility group box 1 (HMGB1) protein on glioblastoma (GBM) progression is still controversial. p62 is overexpressed in glioma...