The developmental genetics of auditory hair cells

• Published in: Human molecular genetics Vol. 13; no. suppl-2; pp. R289 - R296
• Main Authors: Hawkins, R. David, Lovett, Michael
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.10.2004; Oxford Publishing Limited (England)
• Subjects: Animals; Biological and medical sciences; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation, Developmental - physiology; Genetics of eukaryotes. Biological and molecular evolution; Hair Cells, Auditory - physiology; Hearing Loss, Sensorineural - genetics; Humans; Molecular and cellular biology; Hair; Genetics

Loss of auditory hair cells (AHCs) is a major cause of human deafness. Considerable effort has been devoted to unraveling how these mechanotransducers of sound are specified, with a view to correcting hearing loss by gene or stem cell therapies. Recent work on signaling cascades, particularly latera...