Airway hyper-responsiveness in lipopolysaccharide-challenged common marmosets ( Callithrix jacchus )

• Published in: Clinical science (1979) Vol. 126; no. 2; pp. 155 - 162
• Main Authors: Curths, Christoph, Wichmann, Judy, Dunker, Sarah, Windt, Horst, Hoymann, Heinz-Gerd, Lauenstein, Hans D., Hohlfeld, Jens, Becker, Tamara, Kaup, Franz-Josef, Braun, Armin, Knauf, Sascha
• Format: Journal Article
• Language: English
• Published: England Portland Press Ltd 01.01.2014
• Subjects: Animals; Bronchial Hyperreactivity - physiopathology; Bronchoconstriction - drug effects; Callithrix; Female; Lipopolysaccharides; Male; Methacholine Chloride; Original Paper; Plethysmography; Respiratory Function Tests

Animal models with a high predictive value for human trials are needed to develop novel human-specific therapeutics for respiratory diseases. The aim of the present study was to examine lung-function parameters in marmoset monkeys (Callithrix jacchus) that can be used to detect pharmacologically or...