Suprachiasmatic Nucleus Neuropeptide Expression in Patients with Huntington's Disease

• Published in: Sleep (New York, N.Y.) Vol. 36; no. 1; pp. 117 - 125
• Main Authors: van Wamelen, Daniel J., Aziz, N. Ahmad, Anink, Jasper J., van Steenhoven, Robin, Angeloni, Debora, Fraschini, Franco, Jockers, Ralf, Roos, Raymund A. C., Swaab, Dick F.
• Format: Journal Article
• Language: English
• Published: United States Associated Professional Sleep Societies, LLC 01.01.2013
• Subjects: Arginine Vasopressin - metabolism; Chronobiology Disorders - complications; Chronobiology Disorders - metabolism; Circadian Rhythm; Cohort Studies; Female; Humans; Huntington Disease - complications; Huntington Disease - metabolism; Hypothalamus - metabolism; In Situ Hybridization - methods; Male; Neuropeptides - metabolism; Sleep Wake Disorders - complications; Sleep Wake Disorders - metabolism; Suprachiasmatic Nucleus - metabolism; Suprachiasmatic Nucleus in Huntington's Disease; Vasoactive Intestinal Peptide - metabolism

To study whether sleep and circadian rhythm disturbances in patients with Huntington's disease (HD) arise from dysfunction of the body's master clock, the hypothalamic suprachiasmatic nucleus. Postmortem cohort study. Eight patients with HD and eight control subjects matched for sex, age,...