Importance of mechanical signals in promoting exercise-induced improvements in vasomotor function of aged skeletal muscle resistance arteries

• Published in: American journal of physiology. Heart and circulatory physiology Vol. 315; no. 3; pp. H602 - H609
• Main Authors: Woodman, Christopher R, Seawright, John W, Luttrell, Meredith J, Shin, Song Yi, Trache, Andreea
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.09.2018
• Subjects: Aging; Animals; Arteries; Arteries - growth & development; Arteries - physiology; Endurance; Exercise; Humans; Mechanical stimuli; Mechanotransduction, Cellular; Muscle function; Muscle, Skeletal - blood supply; Muscle, Skeletal - growth & development; Muscles; Pressure; Shear stress; Skeletal muscle; Skeletal system; Stress, Mechanical; Vasomotor System - growth & development; Vasomotor System - physiology; endothelium; shear stress; vascular smooth muscle; vasodilation; exercise; vasoconstriction; pressure

Current research indicates that vasomotor responses are altered with aging in skeletal muscle resistance arteries. The changes in vasomotor function are characterized by impaired vasodilator and vasoconstrictor responses. The detrimental effects of aging on vasomotor function are attenuated in some...