Importance of mechanical signals in promoting exercise-induced improvements in vasomotor function of aged skeletal muscle resistance arteries

Current research indicates that vasomotor responses are altered with aging in skeletal muscle resistance arteries. The changes in vasomotor function are characterized by impaired vasodilator and vasoconstrictor responses. The detrimental effects of aging on vasomotor function are attenuated in some...

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Published inAmerican journal of physiology. Heart and circulatory physiology Vol. 315; no. 3; pp. H602 - H609
Main Authors Woodman, Christopher R, Seawright, John W, Luttrell, Meredith J, Shin, Song Yi, Trache, Andreea
Format Journal Article
LanguageEnglish
Published United States American Physiological Society 01.09.2018
Subjects
Aging
Animals
Arteries
Arteries - growth & development
Arteries - physiology
Endurance
Exercise
Humans
Mechanical stimuli
Mechanotransduction, Cellular
Muscle function
Muscle, Skeletal - blood supply
Muscle, Skeletal - growth & development
Muscles
Pressure
Shear stress
Skeletal muscle
Skeletal system
Stress, Mechanical
Vasomotor System - growth & development
Vasomotor System - physiology
endothelium
shear stress
vascular smooth muscle
vasodilation
exercise
vasoconstriction
pressure
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Abstract Current research indicates that vasomotor responses are altered with aging in skeletal muscle resistance arteries. The changes in vasomotor function are characterized by impaired vasodilator and vasoconstrictor responses. The detrimental effects of aging on vasomotor function are attenuated in some vascular beds after a program of endurance exercise training. The signals associated with exercise responsible for inducing improvements in vasomotor function have been proposed to involve short-duration increases in intraluminal shear stress and/or pressure during individual bouts of exercise. Here, we review evidence that increases in shear stress and pressure, within a range believed to present in these arteries during exercise, promote healthy vasomotor function in aged resistance arteries. We conclude that available research is consistent with the interpretation that short-duration mechanical stimulation, through increases in shear stress and pressure, contributes to the beneficial effects of exercise on vasomotor function in aged skeletal muscle resistance arteries.
AbstractList Current research indicates that vasomotor responses are altered with aging in skeletal muscle resistance arteries. The changes in vasomotor function are characterized by impaired vasodilator and vasoconstrictor responses. The detrimental effects of aging on vasomotor function are attenuated in some vascular beds after a program of endurance exercise training. The signals associated with exercise responsible for inducing improvements in vasomotor function have been proposed to involve short-duration increases in intraluminal shear stress and/or pressure during individual bouts of exercise. Here, we review evidence that increases in shear stress and pressure, within a range believed to present in these arteries during exercise, promote healthy vasomotor function in aged resistance arteries. We conclude that available research is consistent with the interpretation that short-duration mechanical stimulation, through increases in shear stress and pressure, contributes to the beneficial effects of exercise on vasomotor function in aged skeletal muscle resistance arteries.
Author Luttrell, Meredith J
Shin, Song Yi
Trache, Andreea
Woodman, Christopher R
Seawright, John W
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  surname: Trache
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  organization: Department of Biomedical Engineering, Texas A&M University , College Station, Texas
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shear stress
vascular smooth muscle
vasodilation
exercise
vasoconstriction
pressure
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Snippet Current research indicates that vasomotor responses are altered with aging in skeletal muscle resistance arteries. The changes in vasomotor function are...
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StartPage H602
SubjectTerms Aging
Animals
Arteries
Arteries - growth & development
Arteries - physiology
Endurance
Exercise
Humans
Mechanical stimuli
Mechanotransduction, Cellular
Muscle function
Muscle, Skeletal - blood supply
Muscle, Skeletal - growth & development
Muscles
Pressure
Shear stress
Skeletal muscle
Skeletal system
Stress, Mechanical
Vasomotor System - growth & development
Vasomotor System - physiology
Title Importance of mechanical signals in promoting exercise-induced improvements in vasomotor function of aged skeletal muscle resistance arteries
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