Transient Encephalopathy with A Single Dose of Oral Metronidazole: A Case Report

Metronidazole (MNZ) is an antibacterial agent widely used in the treatment of anaerobic and protozoal infections, easily penetrating the cerebrospinal fluid and central nervous system. MNZ is well-tolerated, but it can also cause serious neurologic adverse effects such as peripheral neuropathy, atax...

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Bibliographic Details
Published inTürk nöroloji dergisi Vol. 27; no. 1; pp. 82 - 84
Main Authors Altunışık, Erman, Eke Kurt, Şebnem Zeynep
Format Journal Article
LanguageEnglish
Published Türk Nöroloji Derneği 01.03.2021
Galenos Yayinevi
Subjects
electroencephalography
encephalopathy
metronidazole
Tıp
Ankara
Türkiye
electroencephalography
Metronidazol
elektroensefalografi
Metronidazole
encephalopathy
ensefalopati
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Summary:Metronidazole (MNZ) is an antibacterial agent widely used in the treatment of anaerobic and protozoal infections, easily penetrating the cerebrospinal fluid and central nervous system. MNZ is well-tolerated, but it can also cause serious neurologic adverse effects such as peripheral neuropathy, ataxia, dysarthria, convulsion and encephalopathy. MNZ-induced encephalopathy (MIE) is a rare adverse effect. Magnetic resonance imaging and electroencephalography are helpful methods in the diagnosis of the disease. The mechanism of MIE has not been clearly elucidated. Usually, it is completely cured by drug discontinuation. In this report, a reversible encephalopathy developing in a male patient after receiving a single dose of oral MNZ is presented.
ISSN:1301-062X
1309-2545
1309-2545
DOI:10.4274/tnd.2020.47154