Managing risky assets – mitophagy in vivo

• Published in: Journal of cell science Vol. 134; no. 19
• Main Author: Narendra, Derek P.
• Format: Journal Article
• Language: English
• Published: England The Company of Biologists Ltd 01.10.2021
• Subjects: Animals; Autophagy; Mitochondria; Mitochondria - metabolism; Mitophagy; Neurons - metabolism; Oxidative Stress; Parkinson Disease - metabolism; Review; Subject Collection: Autophagy; Ubiquitin-Protein Ligases - genetics; Ubiquitin-Protein Ligases - metabolism; PRKN; Park6; Mitochondria quality control; Neurodegeneration; Park2

Mitochondria, which resemble their α-proteobacteria ancestors, are a major cellular asset, producing energy ‘on the cheap’ through oxidative phosphorylation. They are also a liability. Increased oxidative phosphorylation means increased oxidative stress, and damaged mitochondria incite inflammation...