Mammalian SWI/SNF collaborates with a polycomb-associated protein to regulate male germline transcription in the mouse

• Published in: Development (Cambridge) Vol. 146; no. 19
• Main Authors: Menon, Debashish U., Shibata, Yoichiro, Mu, Weipeng, Magnuson, Terry
• Format: Journal Article
• Language: English
• Published: England The Company of Biologists Ltd 05.07.2019
• Subjects: Acetylation; Animals; Chromatin - metabolism; Chromosomal Proteins, Non-Histone - metabolism; DNA Helicases - metabolism; Epigenesis, Genetic; Gene Expression Regulation, Developmental; Histone Code; Lysine - metabolism; Male; Mammals - genetics; Meiosis - genetics; Mice; Models, Genetic; Nuclear Proteins - metabolism; Polycomb-Group Proteins - metabolism; Promoter Regions, Genetic; Protein Binding - genetics; Spermatogenesis - genetics; Spermatogonia - metabolism; Transcription Factors - metabolism; Transcription, Genetic; SCML2; Transcriptional regulation; BRG1; SWI/SNF chromatin remodeling

A deficiency in BRG1, the catalytic subunit of the SWI/SNF chromatin remodeling complex, results in a meiotic arrest during spermatogenesis. Here, we explore the causative mechanisms. BRG1 is preferentially enriched at active promoters of genes essential for spermatogonial pluripotency and meiosis....