Instrumentation design for hydrodynamic sample injection in microchip electrophoresis: A review

Reproducible and representative sample injection in microchip electrophoresis has been a bottleneck for quantitative analytical applications. Electrokinetic sample injection is the most used because it is easy to perform. However, this injection method is usually affected by sample composition and t...

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Bibliographic Details
Published inElectrophoresis Vol. 33; no. 17; pp. 2614 - 2623
Main Authors Saito, Renata M., Coltro, Wendell K. T., de Jesus, Dosil P.
Format Journal Article
LanguageEnglish
Published Germany Blackwell Publishing Ltd 01.09.2012
Subjects
Analytical instrumentation
Electrophoresis, Microchip - instrumentation
Equipment Design
Lab-on-a-chip
Microchip electrophoresis
Microfluidic Analytical Techniques - instrumentation
Microfluidic devices
Sample injection
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Summary:Reproducible and representative sample injection in microchip electrophoresis has been a bottleneck for quantitative analytical applications. Electrokinetic sample injection is the most used because it is easy to perform. However, this injection method is usually affected by sample composition and the bias effect. On the other hand, these drawbacks are overcome by the hydrodynamic (HD) sample injection, although this injection mode requires HD flow control. This review gives an overview of the basic principles, the instrumentation designs, and the performance of HD sample injection systems for microchip electrophoresis.
Bibliography:FAPESP
CNPq
ark:/67375/WNG-G5RX10PV-T
ArticleID:ELPS4368
istex:1F3BA3E85179B4B22EDC911E2EAA12DB55CE4F75
See the article online to view Figs. 2, 7 and 9 in colour.
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ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0173-0835
1522-2683
DOI:10.1002/elps.201200089