Role of CXCR4‐mediated bone marrow colonization in CNS infiltration by T cell acute lymphoblastic leukemia

• Published in: Journal of leukocyte biology Vol. 99; no. 6; pp. 1077 - 1087
• Main Authors: Jost, Tanja Rezzonico, Borga, Chiara, Radaelli, Enrico, Romagnani, Andrea, Perruzza, Lisa, Omodho, Lorna, Cazzaniga, Giovanni, Biondi, Andrea, Indraccolo, Stefano, Thelen, Marcus, Kronnie, Geertruy, Grassi, Fabio
• Format: Journal Article
• Language: English
• Published: United States 01.06.2016
• Subjects: Adolescent; Animals; blood‐brain barrier; Bone Marrow - drug effects; Bone Marrow - pathology; CCR6; CCR7; Cell Line, Transformed; Cell Line, Tumor; Central Nervous System - drug effects; Central Nervous System - pathology; Child; Child, Preschool; Female; Hematopoietic Stem Cells - drug effects; Hematopoietic Stem Cells - metabolism; Heterocyclic Compounds - pharmacology; Humans; Liver - cytology; Liver - embryology; Male; meninges; Meninges - drug effects; Meninges - pathology; Mice; neuropathology; Phenotype; Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism; Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology; Receptors, Chemokine - metabolism; Receptors, CXCR4 - antagonists & inhibitors; Receptors, CXCR4 - metabolism; Receptors, Notch - metabolism; RNA, Messenger - genetics; RNA, Messenger - metabolism; Stem Cells - cytology; Stem Cells - drug effects; Stem Cells - metabolism; Xenograft Model Antitumor Assays; blood-brain barrier; CCR7; CCR6; neuropathology; meninges

CXCR4 in T‐ALL cells promotes BM colonization, a prelude to meninges invasion and potential pharmacological target for this leukemia. Infiltration of the central nervous system is a severe trait of T cell acute lymphoblastic leukemia. Inhibition of CXC chemokine receptor 4 significantly ameliorates...