Trifluoromethyloxadiazoles: inhibitors of histone deacetylases for control of Asian soybean rust

• Published in: Pest management science Vol. 76; no. 10; pp. 3357 - 3368
• Main Authors: Winter, Christian, Fehr, Marcus, Craig, Ian R, Grammenos, Wassilios, Wiebe, Christine, Terteryan‐Seiser, Violeta, Rudolf, Georg, Mentzel, Tobias, Quintero Palomar, Maria Angelica
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.10.2020; Wiley Subscription Services, Inc
• Subjects: Aspergillus nidulans; Basidiomycota; Crop diseases; crop protection; Crystal structure; enzyme inhibition; enzyme inhibitors; Enzymes; Fungi; Fungicides; Fungicides, Industrial; Glycine max; Histone deacetylase; Histone Deacetylases; Histones; Humans; Inhibitors; mechanism of action; Pesticides; Phakopsora pachyrhizi; Plant diseases; plant pathogens; rust diseases; Rust fungi; soybean rust; Soybeans; structure-activity relationships; Trifluoromethyloxadiazoles; histone deacetylases; rust diseases; fungicides; Trifluoromethyloxadiazoles; crop protection

BACKGROUND Trifluoromethyloxadiazoles (TFMOs) are selective inhibitors of class II histone deacetylases (HDACs). To date, class II HDACs have not been addressed as target enzymes by commercial fungicides. RESULTS Antifungal testing of a broad variety of TFMOs against several important plant pathogen...