Regional Aβ-tau interactions promote onset and acceleration of Alzheimer’s disease tau spreading

• Published in: Neuron (Cambridge, Mass.) Vol. 110; no. 12; pp. 1932 - 1943.e5
• Main Authors: Lee, Wha Jin, Brown, Jesse A., Kim, Hye Ryun, La Joie, Renaud, Cho, Hanna, Lyoo, Chul Hyoung, Rabinovici, Gil D., Seong, Joon-Kyung, Seeley, William W.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.06.2022
• Subjects: Acceleration; Alzheimer Disease - metabolism; Alzheimer’s disease; Amyloid beta-Peptides - metabolism; amyloid-beta; Brain - metabolism; connectome; Cross-Sectional Studies; DTI; Humans; PET; Positron-Emission Tomography - methods; tau; tau Proteins - metabolism; amyloid-beta; DTI; tau; connectome; Alzheimer’s disease; PET

Amyloid-beta and tau are key molecules in the pathogenesis of Alzheimer’s disease, but it remains unclear how these proteins interact to promote disease. Here, by combining cross-sectional and longitudinal molecular imaging and network connectivity analyses in living humans, we identified two amyloi...