Analysis of RPA190 revealed multiple positively selected mutations associated with metalaxyl resistance in Phytophthora infestans

• Published in: Pest management science Vol. 74; no. 8; pp. 1916 - 1924
• Main Authors: Chen, Fengping, Zhou, Qian, Xi, Jing, Li, Dong‐liang, Schnabel, Guido, Zhan, Jiasui
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.08.2018; Wiley Subscription Services, Inc
• Subjects: Amino acids; China; correlation; evolution; fungicide resistance; Fungicides; Gene sequencing; genes; Glycine; median effective concentration; Metalaxyl; Mutation; nucleotide sequences; Organic chemistry; Phylogeny; Phytophthora infestans; point mutation; Positive selection; RPA190 gene; Valine; China; Phytophthora infestans; fungicide resistance; evolution; RPA190 gene

BACKGROUND Metalaxyl is a phenylamide fungicide, introduced for oomycete management in the 1970s. RPA190 gene has been reported to be associated with metalaxyl resistance, although other genes may also be involved in the process. This study assessed the evolutionary association of amino acid (AA) mu...