Targeting of phosphorylated tau at threonine 181 by a Qβ virus‐like particle vaccine is safe, highly immunogenic, and reduces disease severity in mice and rhesus macaques - Maphis, Nicole M.; Hulse, Jonathan; Peabody, Julianne; Dadras, Somayeh; Whelpley, Madelin J; Kandath, Manas; Wilson, Colin; Hobson, Sasha; Thompson, Jeff; Poolsup, Suttinee; Beckman, Danielle; Ott, Sean P; et al. (Alzheimer's & dementia, 2025)
Keywords: Alzheimer Disease - immunology; Alzheimer's disease; Animals; Brain - pathology; Disease Models, Animal; Female; hTau; Humans; immunotherapy; Macaca mulatta; Male; Mice; mild cognitive impairment; non‐human primates; Phosphorylation; PS19; pT181; rhesus macaques; tau; tau Proteins - immunology; tau Proteins - metabolism; tauopathies; Tauopathies - immunology; Threonine - immunology; vaccines; Vaccines, Virus-Like Particle - immunology; virus‐like particles; hTau; rhesus macaques; vaccines; virus‐like particles; immunotherapy; non‐human primates; pT181; tau; mild cognitive impairment; tauopathies; Alzheimer's disease; PS19