Impact of GADD34 on Apoptosis of Tonsillar Mononuclear Cells from IgA Nephropathy Patients by Regulating Eif2α Phosphorylation

• Published in: Cellular physiology and biochemistry Vol. 50; no. 6; pp. 2203 - 2215
• Main Authors: Peng, Xiaofei, Yang, Tao, He, Liyu, Chen, Xian, Jiang, Yafeng, Zhang, Hao, Liu, Hong, Peng, Youming
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.11.2018; Cell Physiol Biochem Press GmbH & Co KG
• Subjects: Adolescent; Adult; Apoptosis; Autophagy; Cell apoptosis; Cells, Cultured; DNA damage; Endoplasmic reticulum; ER stress; Eukaryotic Initiation Factor-2 - metabolism; Female; GADD34; Glomerulonephritis, IGA - metabolism; Glomerulonephritis, IGA - pathology; Guanabenz - pharmacology; Heat-Shock Proteins - metabolism; Homeostasis; Humans; IgA nephropathy; Immunoglobulin A - metabolism; Immunoglobulins; Inflammation; Male; Middle Aged; Original Paper; Palatine Tonsil - cytology; Palatine Tonsil - drug effects; Palatine Tonsil - metabolism; Phosphorylation; Protein folding; Protein Phosphatase 1 - antagonists & inhibitors; Protein Phosphatase 1 - genetics; Protein Phosphatase 1 - metabolism; Protein synthesis; RNA Interference; RNA, Small Interfering - metabolism; Tonsillar mononuclear cell; Tonsillitis; Transcription Factor CHOP - metabolism; Young Adult; United States > US; Tonsillar mononuclear cell; GADD34; ER stress; IgA nephropathy; Cell apoptosis

Background/Aims: Tonsillectomy may be an important method to achieve a long-term remission of IgAN, but patients’ physical status may limit their access to this surgery. We proposed an encouraging solution through inhibiting GADD34 expression in order to promote tonsillar mononuclear cells (TMCs) ap...