Downregulation of Stearoyl-CoA Desaturase 1 (SCD-1) Promotes Resistance to Imatinib in Chronic Myeloid Leukemia

• Published in: Mediterranean journal of hematology and infectious diseases Vol. 15; no. 1; p. e2023008
• Main Authors: Altinok Gunes, Buket, Hekmatshoar, Yalda, Ozkan, Tulin, Bozkurt, Sureyya, Erdogan Aydos, O Sena, Buyukasik, Yahya, Aladag, Elifcan, Sunguroglu, Asuman
• Format: Journal Article
• Language: English
• Published: Italy Università Cattolica del Sacro Cuore 2023; Mattioli1885
• Subjects: BCR-ABL mutations; CML; Imatinib resistance; Original; sCD-1; SCD-1; BCR-ABL mutations; CML; Imatinib resistance

Chronic myeloid leukemia (CML) is a malignant hematopoietic stem cell disease resulting in the fusion of BCR and ABL genes and characterized by the presence of the reciprocal translocation t(9;22)(q34;q11). BCR-ABL, a product of the BCR-ABL fusion gene, is a structurally active tyrosine kinase and p...