Association of the GSTM1 null polymorphism with breast cancer in a Mexican population

• Published in: Genetics and molecular research Vol. 14; no. 4; pp. 13066 - 13075
• Main Authors: Soto-Quintana, O, Zúñiga-González, G M, Ramírez-Patiño, R, Ramos-Silva, A, Figuera, L E, Carrillo-Moreno, D I, Gutiérrez-Hurtado, I A, Puebla-Pérez, A M, Sánchez-Llamas, B, Gallegos-Arreola, M P
• Format: Journal Article
• Language: English
• Published: Brazil 26.10.2015
• Subjects: Adult; Alleles; Breast Neoplasms - epidemiology; Breast Neoplasms - genetics; Case-Control Studies; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Glutathione Transferase - genetics; Humans; Mexico - epidemiology; Middle Aged; Odds Ratio; Polymorphism, Genetic; Population Surveillance; Risk Factors; Mexico

The glutathione S transferase (GST) family plays an important role in the processing of carcinogens. Data on the null GSTM1 genotype has revealed associations with cancer, and has been suggested to affect carcinogen metabolism and to contribute to tumor promotion in the mammary gland. We examined th...